Biosourced polymeric cryogels for future biomedical applications with remarkable antimicrobial activities and tribological properties

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dc.authoridMutlu, Dogukan/0000-0003-3259-5822en_US
dc.authorscopusid58914173900en_US
dc.authorscopusid55939623800en_US
dc.authorscopusid57206722539en_US
dc.authorscopusid57198420880en_US
dc.authorscopusid57212511655en_US
dc.authorscopusid55939426500en_US
dc.authorscopusid36117534100en_US
dc.authorwosidMutlu, Dogukan/AAL-4976-2021en_US
dc.contributor.authorGurel, Cansu Meltem
dc.contributor.authorBozbeyoglu, Naime Nur
dc.contributor.authorYardimci, Berna Kavakcioglu
dc.contributor.authorSarkaya, Koray
dc.contributor.authorMutlu, Dogukan
dc.contributor.authorAkincioglu, Sitki
dc.contributor.authorDogan, Nazime Mercan
dc.date.accessioned2024-08-23T16:04:37Z
dc.date.available2024-08-23T16:04:37Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractCryogels, known as a subclass of hydrogels, are promising biomaterials to use in various biotechnological fields. In recent years, applications of antimicrobial hydrogels with improved antimicrobial activities, high biocompatibility, and physicochemical stability have attracted attention as an alternative to using antimicrobial drugs against microbial interactions that may threaten human health, which may even result in death. In this paper, we investigated in detail the biological activities and tribological performances of the previously characterized 2hydroxyethyl methacrylate (HEMA)-based amphiphilic cryogels (PHEMA-PLinaOH) (HC series) that contain hydroxylated polymeric linoleic acid (PLinaOH) as biosource. The biocompatibilities of these cryogels were examined against human embriyonic kidney (HEK293) cell line with MTT assay and acridine orange/ethidium bromide (AO/EB) dual staining. The antimicrobial activities of the materials were extensively investigated against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa PA01 besides four different strains of the yeast Saccharomyces cerevisiae BY4741 by using biofilms eradication, antibiofilm activity and colony forming unit assays. Additionally, the possible morphological changes in microbial cells were evaluated by taking FESEM images. The tribological performances of the cryogels were evaluated in terms of their applicability for future biomedical applications such as artificial articular cartilage or tissue scaffold. Our results showed that while the cryogels did not show significant inhibition on HEK293 cell viability and intensive live cell population was observed after AO/EB staining, they exerted remarkable antimicrobial activities against all studied bacterial and fungal strains. The morphological deformations including the decrease in EPS density and formation of holes were recorded for bacteria and yeast cells with FESEM images, respectively. Finally, it was determined that the increase in the fatty acid ratio contributes positively to tribological properties of the cryogels. All the results indicate that these polymeric cryogels might be considered potential biomaterials for future tissue-engineering studies.en_US
dc.identifier.doi10.1016/j.mtcomm.2024.108387
dc.identifier.issn2352-4928
dc.identifier.scopus2-s2.0-85186437364en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.mtcomm.2024.108387
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14293
dc.identifier.volume38en_US
dc.identifier.wosWOS:001204889900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMaterials Today Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial hydrogelsen_US
dc.subjectCryogelsen_US
dc.subjectHydroxylated fatty acidsen_US
dc.subjectBiocompatibilityen_US
dc.subjectAntibiofilm activityen_US
dc.subjectPolymicrobial biofilmen_US
dc.subjectAntifungal activityen_US
dc.subjectLinoleic-Aciden_US
dc.subjectHydrogelsen_US
dc.subjectOilen_US
dc.subjectAntibiofilmen_US
dc.subjectAdsorptionen_US
dc.titleBiosourced polymeric cryogels for future biomedical applications with remarkable antimicrobial activities and tribological propertiesen_US
dc.typeArticleen_US

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