Hemophilic arthropathy in children: Pathophysiology, diagnosis and management

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dc.authorscopusid57235618200
dc.authorscopusid23768513300
dc.contributor.authorTurhan, B.
dc.contributor.authorTurhan, Y.
dc.date.accessioned2021-12-01T18:38:49Z
dc.date.available2021-12-01T18:38:49Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractArthropathy is a serious and common problem in patients with hemophilia impairing the patient’s quality of life seriously. The most commonly affected joints in hemophilic arthropathy are knees, ankles and elbows. Even a single bleeding could cause devastating effects to synovium, cartilage and also subchondral bones. Ultrasound and magnetic resonance imaging have been advocated for the studying of cartilage damage. Prophylaxis has been demonstrated as a standard choice of management to prevent hemophilic arthropathy development. Primary prophylaxis starting at early years of age is very important to prevent hemorrhages but secondary prophylaxis in adolescents has also significant success rates. As the duration of exposure to the blood increases in the joint cavity, degeneration of the cartilage matrix and resultant cartilage loss also increase, so the aspiration of the hematoma from joint plays an important role in prevention of the disease progression. Synovectomy may be required in cases where prophylaxis and aspiration does not prevent the recurrent hemorrhages. The purpose of synovectomy either with medical or surgical methods is to remove the problematic synovium to prevent the progression of hemophilic arthropathy. Medical synovectomy (synoviorthesis) has two basic types; radiosynovectomy and chemical synovectomy and the former one is appearing to be more effective with an about 85% success rates. If all of these measures fail to prevent the progressive cartilage damage, open or arthroscopic synovectomy, arthrodesis of the affected joint or even arthroplasty could be necessary. Here we tried to summarize the pathological mechanism, diagnosis and management of hemophilic arthropathy in children. © 2021, Duzce University Medical School. All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.909300
dc.identifier.endpage128en_US
dc.identifier.issn1307671X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85113770411en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage123en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.909300
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9852
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArthropathyen_US
dc.subjectDiagnostic imagingen_US
dc.subjectHemophiliaen_US
dc.subjectSynovitisen_US
dc.titleHemophilic arthropathy in children: Pathophysiology, diagnosis and managementen_US
dc.typeReview Articleen_US

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