Investigation of Permeability of Thiocolchicoside Through Transdermal Drug Delivery System Using Franz Diffusion Cell

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dc.contributor.authorKaragüzel, Hale
dc.contributor.authorÖzak, Sezen Sivrikaya
dc.contributor.authorDalmaz, Aslıhan
dc.date.accessioned2025-03-24T19:47:06Z
dc.date.available2025-03-24T19:47:06Z
dc.date.issued2024
dc.departmentDüzce Üniversitesi
dc.description.abstractRecently, drug release applications through the skin have become very popular. One of the most remarkable of these drug release applications is transdermal drug release systems, which are drug release methods that allow the active substance to pass into the systemic circulation through the skin or artificial membranes. In this study, the optimization conditions required for the release and permeation tests of a gel drug containing the active substance thiocolchicoside were comparatively investigated using synthetic membranes without human or animal skin. For this purpose, the permeability of the gel drug in gel form and the active ingredient thiocolchicoside was carried out using Franz Diffusion Cell. As a result of the investigations, it was observed that the best synthetic membrane for the permeability of thiocolchicoside in the Franz Diffusion Cell was the Supor membrane. In addition, the method's relative standard deviation values, detection, and quantification limits were determined, and permeation studies were carried out. In this study, the correlation coefficient was found to be 0.9992, and the limits of detection and quantification were 0.026 and 0.078 µg/L. In this way, the sensitivity and reliability of the validation study were determined.
dc.identifier.doi10.16984/saufenbilder.1456568
dc.identifier.endpage815
dc.identifier.issn2147-835X
dc.identifier.issue4
dc.identifier.startpage804
dc.identifier.urihttps://doi.org/10.16984/saufenbilder.1456568
dc.identifier.urihttps://hdl.handle.net/20.500.12684/18484
dc.identifier.volume28
dc.language.isoen
dc.publisherSakarya Üniversitesi
dc.relation.ispartofSakarya University Journal of Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250324
dc.subjectThiocolchicoside|Franz diffusion cell|Synthetic membranes|Transdermal drug delivery system|HPLC
dc.titleInvestigation of Permeability of Thiocolchicoside Through Transdermal Drug Delivery System Using Franz Diffusion Cell
dc.typeArticle

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