Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction

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dc.contributor.authorShelest, Borys
dc.contributor.authorKopytsya, Mykola
dc.contributor.authorHilova, Yaroslava
dc.contributor.authorRodionova, Yuliia
dc.contributor.authorPolivenok, Igor
dc.date.accessioned2023-04-10T20:20:56Z
dc.date.available2023-04-10T20:20:56Z
dc.date.issued2021
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: The aim of the study was to investigate the relationship between the soluble suppression of tumorigenicity 2 (sST2) level and the degree of epicardial blood flow recovery in patients with myocardial infarction with ST-segment elevation (STEMI) after percutaneous coronary intervention. Material and Methods: The study involved 61 patients (83.6% males), with a mean age of 59.85±10.01 years. sST2 level was measured by enzyme immunoassay. Patients were divided into two groups. The first group (n=12) included patients with thrombolysis in myocardial infarction (TIMI) ?II flow grade, the second group (n=49) with TIMI III flow grade. Results: The sST2 level was significantly higher in the first hours of the disease in the group with decreased epicardial blood flow (TIMI ?II) after percutaneous coronary intervention (p=0.003). Receiver operating characteristics curve analysis showed that sST2 levels over 34.2 ng/ml, detected on admission, was an independent predictor of adverse revascularization (TIMI ?II) in patients with STEMI with a sensitivity of 92.3% and a specificity of 62.5%; the area under curve was 0.811 (95% CI: 0.651 - 0.873; p=0.001). Both the univariate (OR: 1.020, 95% CI: 1.001-1.041, p=0.028) and multivariate (OR: 1.030; 95% CI: 1.002-1.057; p=0.033) analyzes showed that sST2 was a significant predictor of the unfavorable outcome of epicardial vascular revascularization (TIMI ???). Conclusion: sST2 is highly associated with the degree of blood flow recovery after percutaneous coronary intervention in patients with STEMI and is of great clinical importance as a prognostic marker.en_US
dc.identifier.doi10.18678/dtfd.889947
dc.identifier.endpage180en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.startpage174en_US
dc.identifier.trdizinid498451en_US
dc.identifier.urihttp://doi.org/10.18678/dtfd.889947
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/498451
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11478
dc.identifier.volume23en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectno-reflow phenomenonen_US
dc.subjectPercutaneous Coronary Interventionen_US
dc.subjectacute myocardial infarctionen_US
dc.subjectsST2en_US
dc.titleSoluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarctionen_US
dc.typeArticleen_US

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