Investigation of Total Phenolic Content of Tilia dasystyla and Polygonatum orientale Desf Extracts and Their Cytotoxic Effect on the Osteogenic Sarcoma (Saos-2) Cancer Cell Line

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dc.authoridZarringhalami, Roshanak/0000-0003-0104-2395
dc.authoridHanachi, Parichehr/0000-0002-6450-203X
dc.authorwosidHanachi, Parichehr/T-8487-2019
dc.authorwosidAgan, Aydan/AAW-9007-2020
dc.contributor.authorZarringhalami, Roshanak
dc.contributor.authorHanachi, Parichehr
dc.contributor.authorKaya, Ertugrul
dc.contributor.authorAgan, Aydan Fulden
dc.contributor.authorAgan, Kagan
dc.contributor.authorDonmez, Mert
dc.date.accessioned2021-12-01T18:49:42Z
dc.date.available2021-12-01T18:49:42Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractBackground: Osteosarcoma; is one of the most common malignant tumors. Nowadays, because of the many side effects of cancer drugs, the usage of herbal medicine which can inhibit or eliminate cancer cells by their antioxidant compounds is increased. Objectives: In the present study anticancer effect of Tilia dasystyla and Polygonatum orientale Desf different extracts on osteogenic sarcoma (Saos-2) cancer cell line was investigated and their polyphenolic compounds were identified by liquid chromatography-mass spectrometry (LC-MS) analysis. The cytotoxic effect of these extracts on Saos-2 cell line and identification of their phenolic compounds have not been reported so far. Methods: Cancer cell lines were provided from Department of Biological Sciences, Bursa University, Turkey. Different concentrations of the methanol, ethanol, and diluted water extracts (0.5 - 5 mg/mL) were tested on Saos-2 cell line. After 24, 48, and 72 hours, the cell viability was evaluated using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. For the investigation of total phenolic compounds of T. dasystyla and P. orientale Desf extracts LC-MS method was applied. Results: According to the results diluted water extracts on the Saos-2 cancer cell line showed more cytotoxic effect than other solvents. The lowest IC50 value was 0.58 +/- 0.01 mg/mL within 72 hours belonged to T. dasystyla water extract. Conclusions: Tilia dasystyla and Polygonatum orientale Desf extracts contain some polyphenolic compounds which showed cytotoxic effect on Saos-2 cancer cell line. The full potential of these herbal extracts is yet to be realized by further studies on animal models and subsequent trials.en_US
dc.description.sponsorshipDuzce University, TurkeyDuzce University; Alzahra University, Iranen_US
dc.description.sponsorshipThe study was supported by Duzce University, Turkey and Alzahra University, Iran.en_US
dc.identifier.doi10.5812/ijcm.94130
dc.identifier.issn2538-4422
dc.identifier.issn2538-497X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85079895642en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.5812/ijcm.94130
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10765
dc.identifier.volume13en_US
dc.identifier.wosWOS:000518426500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKowsar Publen_US
dc.relation.ispartofInternational Journal Of Cancer Managementen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-Canceren_US
dc.subjectLC-MSen_US
dc.subjectPolygonatum orientale Desfen_US
dc.subjectSaos-2en_US
dc.subjectTilia dasystylaen_US
dc.subjectCordata Mill.en_US
dc.subjectApoptosisen_US
dc.subjectAntioxidanten_US
dc.subjectProliferationen_US
dc.subjectAutophagyen_US
dc.subjectOdoratumen_US
dc.subjectArresten_US
dc.titleInvestigation of Total Phenolic Content of Tilia dasystyla and Polygonatum orientale Desf Extracts and Their Cytotoxic Effect on the Osteogenic Sarcoma (Saos-2) Cancer Cell Lineen_US
dc.typeArticleen_US

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