Can serum NSE and S100-? protein levels predict central nervous system injury in patients with carbon dioxide retention?

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dc.authorscopusid36159707800
dc.authorscopusid57218907518
dc.authorscopusid34771856000
dc.contributor.authorGunes, H.
dc.contributor.authorCandar, M. M.
dc.contributor.authorSaritas, A.
dc.date.accessioned2021-12-01T18:39:01Z
dc.date.available2021-12-01T18:39:01Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractObjectives: To evaluate whether serum neuron specific enolase (NSE) or S100-? protein levels are helpful in predicting central nervous system (CNS) injury in patients with carbon dioxide (CO2) retention Design: A case-control study Setting: This study was performed in the Emergency Department of a University Hospital which functions as the only tertiary center in the city. Subjects: One hundred patients who were admitted to the emergency department and seen to have an arterial partial carbon dioxide pressure above 45 mmHg were included as the study group and 48 healthy volunteers as the control group. Interventions: None Main outcome measures: Possible elevations in serum NSE and/or S100-? protein levels in the study group were main outcome measures. The levels of these markers were measured using enzyme-linked immunoassay kits, and mean values of these parameters were compared between the study and the control groups. Results: Mean NSE level was found to be 69.45 ± 36.39 ng/ ml, and mean S100-? level was 160.57 ± 54.05 pg/ml in the study group. Mean NSE and S100-? levels of the control group were 30.99 ± 20.04 ng/ml and 129.31 ± 415.17 pg/ml, respectively. Mean NSE levels differed significantly between the study and control groups; however, mean S100-? levels did not. Conclusions: The results of the present study suggest that NSE can be used to predict CNS injury in patients with CO2 retention, but S100-? protein cannot. New studies including larger number of patients are needed to obtain more accurate results on this topic. © 2020, Kuwait Medical Association. All rights reserved.en_US
dc.description.sponsorshipWe would like to thank the Scientific Research Projects Foundation of Duzce University for their financial support to the study.en_US
dc.identifier.endpage168en_US
dc.identifier.issn00235776
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85090698227en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9964
dc.identifier.volume52en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKuwait Medical Associationen_US
dc.relation.ispartofKuwait Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbon dioxide retentionen_US
dc.subjectCentral nervous system injuryen_US
dc.subjectHypercapniaen_US
dc.subjectNeuron-specific enolaseen_US
dc.subjectS100-?en_US
dc.titleCan serum NSE and S100-? protein levels predict central nervous system injury in patients with carbon dioxide retention?en_US
dc.typeArticleen_US

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