Can serum NSE and S100-? protein levels predict central nervous system injury in patients with carbon dioxide retention?

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Küçük Resim

Tarih

2020

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Kuwait Medical Association

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Objectives: To evaluate whether serum neuron specific enolase (NSE) or S100-? protein levels are helpful in predicting central nervous system (CNS) injury in patients with carbon dioxide (CO2) retention Design: A case-control study Setting: This study was performed in the Emergency Department of a University Hospital which functions as the only tertiary center in the city. Subjects: One hundred patients who were admitted to the emergency department and seen to have an arterial partial carbon dioxide pressure above 45 mmHg were included as the study group and 48 healthy volunteers as the control group. Interventions: None Main outcome measures: Possible elevations in serum NSE and/or S100-? protein levels in the study group were main outcome measures. The levels of these markers were measured using enzyme-linked immunoassay kits, and mean values of these parameters were compared between the study and the control groups. Results: Mean NSE level was found to be 69.45 ± 36.39 ng/ ml, and mean S100-? level was 160.57 ± 54.05 pg/ml in the study group. Mean NSE and S100-? levels of the control group were 30.99 ± 20.04 ng/ml and 129.31 ± 415.17 pg/ml, respectively. Mean NSE levels differed significantly between the study and control groups; however, mean S100-? levels did not. Conclusions: The results of the present study suggest that NSE can be used to predict CNS injury in patients with CO2 retention, but S100-? protein cannot. New studies including larger number of patients are needed to obtain more accurate results on this topic. © 2020, Kuwait Medical Association. All rights reserved.

Açıklama

Anahtar Kelimeler

Carbon dioxide retention, Central nervous system injury, Hypercapnia, Neuron-specific enolase, S100-?

Kaynak

Kuwait Medical Journal

WoS Q Değeri

Scopus Q Değeri

N/A

Cilt

52

Sayı

2

Künye