Cotinine Effects on Peripheral Nerve Injuries: An Experimental Study

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dc.contributor.authorAkdağ, Rıfat
dc.contributor.authorDalgıç, Ali
dc.contributor.authorSoylu, Uğur
dc.contributor.authorÇağıl, Emin
dc.contributor.authorTake, Gülnur
dc.date.accessioned2023-04-10T20:20:56Z
dc.date.available2023-04-10T20:20:56Z
dc.date.issued2021
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: Cigarette smoking is a common addictive manner and one of the greatest threats to health. Nicotine is one of the main components of cigarette. The aim of this study was to reveal the effect of cotinine which is an active metabolite of nicotine, on peripheral nerve injury in rats. Material and Methods: We studied 42 male adult albino-Wistar rats that were divided into three groups with simple randomization method. Group 1 were given Cotinine® (C-5923-sigma) intraperitoneally, at a dose of 0.3 mg/kg/day for 21 days. Group 2 were given ethyl alcohol, the solvent of Cotinine in the same way, dose and period. Group 3 were subjected to sciatic nerve compression injury by a clip, which has a closing pressure of 50 gr/cm2. Group 1 and 2 were subjected to the same type of injury at the end of 21 days. Four weeks later after trauma, both three groups were sacrificed and injured sciatic nerve sections are taken for histopathological analysis. Results: It was observed that cotinine aggravated the traumatic degeneration and as privileged caused to fibrosis. In the Schwann cells of thick-myelinated fibers exhibited higher grades of degeneration and mitochondrial augmentation. According to the multiple comparison results, the number of Wallerian degenerations in the trauma group was significantly lower than in both the drug-control (p=0.016) and drug (p<0.001) groups. This situation was estimated as a response to oxidative stress. Conclusion: This study reveals that peripheral nerve regeneration after traumatic injury may be affected negatively in smokers.en_US
dc.identifier.doi10.18678/dtfd.892654
dc.identifier.endpage163en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.startpage157en_US
dc.identifier.trdizinid498447en_US
dc.identifier.urihttp://doi.org/10.18678/dtfd.892654
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/498447
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11475
dc.identifier.volume23en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCigaretteen_US
dc.subjectPeripheral Nerveen_US
dc.subjectCotinineen_US
dc.subjectNikotineen_US
dc.subjectTraumaen_US
dc.titleCotinine Effects on Peripheral Nerve Injuries: An Experimental Studyen_US
dc.typeArticleen_US

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