Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls

Basit Öğe Kaydı
dc.contributor.authorYektaş, Çiğdem
dc.contributor.authorAlpay, Merve
dc.contributor.authorTufan, Ali Evren
dc.date.accessioned2020-04-30T22:41:24Z
dc.date.available2020-04-30T22:41:24Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionYektas, Cigdem/0000-0002-5951-7253; TUFAN, ALI EVREN/0000-0001-5207-6240en_US
dc.descriptionWOS: 000479040000001en_US
dc.descriptionPubMed: 31496704en_US
dc.description.abstractObjective: We aimed to investigate the serum concentrations of vitamin B12, folate and homocysteine in children diagnosed with attention deficit hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and healthy controls. Materials and methods: Serum vitamin B12, folate and homocysteine concentrations were measured in 118 children (48 children diagnosed with ADHD, 35 children diagnosed with ASD and 35 healthy controls). Symptom severity in the ADHD and ASD groups was evaluated by the Childhood Autism Rating Scale and Turgay-DSM-1V-Based Screening and Assessment Scale for Disruptive Behavior Disorders. Multivariate analysis of covariance was used to evaluate the effects of diagnosis and gender on biochemical parameters. Results: The ADHD and ASD groups and the healthy controls differed significantly regarding vitamin B12 and homocysteine concentrations, but not folate levels. Patients with ASD had the lowest vitamin B12 and the highest homocysteine levels. Vitamin B12 levels correlated negatively with hyperactivity and/orimpulsivity and oppositionality symptoms in children with ADHD. There were no relationships between psychometric evaluations and laboratory measurements in children with ASD. Gender did not affect vitamin concentrations. Conclusion: Previous studies found that vitamin B12 was reduced while homocysteine was elevated among patients with ADHD and ASDs. Our results also support those reported previously. Oppositionality and hyperactivity and/orimpulsivity may be related to vitamin B12 and homocysteine levels in children with ADHD. Further studies are required to define the role of these parameters and effects on the etiology and clinical manifestations of ASD and ADHD.en_US
dc.description.sponsorshipDuzce UniversityDuzce Universityen_US
dc.description.sponsorshipThis study was supported by the Duzce University coordinatorship of scientific research projects. This study was presented as an oral presentation at the Child and Adolescent Mental Health Congress, Istanbul, 2018 This study was conducted at the Duzce University Biochemistry Laboratory. We thank the laboratory staff, and all the patients and their families for participating in the study.en_US
dc.identifier.doi10.2147/NDT.S212361en_US
dc.identifier.endpage2219en_US
dc.identifier.issn1178-2021
dc.identifier.startpage2213en_US
dc.identifier.urihttps://doi.org/10.2147/NDT.S212361
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3181
dc.identifier.volume15en_US
dc.identifier.wosWOS:000479040000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofNeuropsychiatric Disease And Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectvitamin B12en_US
dc.subjectfolateen_US
dc.subjecthomocysteineen_US
dc.subjectattention deficit hyperactivity disorderen_US
dc.subjectautism spectrum disorderen_US
dc.titleComparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controlsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
3181.pdf
Boyut:
425.37 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu