Protective Effect of Erythropoietin on post-MI Liver Tissue

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dc.contributor.authorGülen, Meltem İçkin
dc.contributor.authorErcan, Feriha
dc.contributor.authorKaya, Özlem Tuğçe Çilingir
dc.contributor.authorBağla, Aysel Güven
dc.date.accessioned2023-04-10T20:31:06Z
dc.date.available2023-04-10T20:31:06Z
dc.date.issued2022
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: Cardiac hepatopathy arises due to heart failure and influences has effects on heart recovery after myocardial infarction (MI).The aim of this study was to investigate the protective effect of Erythropoietin (EPO) on liver tissue exposed to ischemia due to MI. Material and Methods: Experimental MI was established by left anterior descending coronary artery ligation (CAL) and EPO or saline was injected immediately after CAL to five groups of rats, which groups are Control, Saline, EPO 5000, EPO 10000, CAL+1h. CAL+1h group was sacrificed one hour after CAL without any treatment. Other groups were sacrificed six hours after the operation. Liver tissues were examined histopathologically by Hematoxylin Eosin (HE) staining and electron microscopy. Results: Degenerative changes in liver tissue such as vacuolization, sinusoidal dilatation, hepatocyte pyknosis, Kuppfer cell activation were observed. Vacuolization, and sinusoidal dilatation increased in the Saline group compared to the control group (p=0.010 for both). Degenerated hepatocytes with pyknotic nuclei as well as activated Kuppfer cells were decreased in the EPO 10000 group compared to the Saline group (p=0.009), and activated Kupfer cells were decreased compared to the Saline and CAL+1h groups (p=0.035 and p=0.019, respectively). Conclusion: EPO protected liver tissue from histopathological damages regardless of dose, when given at the time of MI. EPO, when given immediately after MI, protected liver tissue from histopathological damage regardless of dose. Considering the mutual interaction of liver and heart,applying EPO to MI patients at first sight may prevent post-MI liver damage and contribute to the recovery of the heart.en_US
dc.identifier.doi10.33631/sabd.1113944
dc.identifier.endpage269en_US
dc.identifier.issn2792-0542
dc.identifier.issue2en_US
dc.identifier.startpage263en_US
dc.identifier.trdizinid516663en_US
dc.identifier.urihttp://doi.org/10.33631/sabd.1113944
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/516663
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12068
dc.identifier.volume12en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofSağlık Bilimlerinde Değer (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectliveren_US
dc.subjectischemiaen_US
dc.subjectCardiac hepatopathyen_US
dc.subjectmyocardial infarctionen_US
dc.subjecterythropoietinen_US
dc.titleProtective Effect of Erythropoietin on post-MI Liver Tissueen_US
dc.typeArticleen_US

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