The known about next-generation sequencing (NGS) [Yeni nesil dizileme (YND) hakkında bilinenler]

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dc.contributor.authorDoğan, Mustafa
dc.contributor.authorEröz, Recep
dc.contributor.authorYüce, Hüseyin
dc.contributor.authorÖzmerdivenli, Recep
dc.date.accessioned2020-04-30T13:33:45Z
dc.date.available2020-04-30T13:33:45Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe Next-Generation Sequencing (NGS) method is based on by forming a library with a plurality of DNA fragments by cutting the base DNA with enzymatic reactions and the amplification of DNA fragments constituting the library. According to OMIM statistics, there are now more than 6,000 single gene disorders and molecular basis of nearly two thirds of these disorder is unknown. A great deal of progress has begun to be made in understanding the molecular basis of many diseases depending on the development of NGS platforms. With NGS technology, in addition to whole genomes and whole exome sequencing, a large number of genes can be sequenced for the etiology of diseases with genetic heterogeneity using target-oriented NGS panels at the same time. With the description of genetic etiology that causes diseases, patients can be given more accurate genetic counseling and family members under risk can be quickly screened. It is possible to reveal the genetic basis of phenotypic and genotypic heterogeneous diseases with the development of new generation lineage analyzes. To the best of our knowledge, there are no Turkish review except for a few English review written about NGS so far. For this reason, it is tried to present to readers what is known about NGS in this review. © 2017, Duzce University Medical School. All rights reserved.en_US
dc.identifier.endpage30en_US
dc.identifier.issn1307671X
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/721
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDNA sequence analyzing; NGS; Sequenceen_US
dc.titleThe known about next-generation sequencing (NGS) [Yeni nesil dizileme (YND) hakkında bilinenler]en_US
dc.typeReview Articleen_US

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