Cytotoxic double arene ruthenium metalla-cycles that overcome cisplatin resistance

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dc.contributor.authorOrhan, Ersin
dc.contributor.authorGarci, Amine
dc.contributor.authorRiedel, Tina
dc.contributor.authorSoudani, Mylene
dc.contributor.authorDyson, Paul J.
dc.contributor.authorTherrien, Bruno
dc.date.accessioned2020-05-01T09:11:16Z
dc.date.available2020-05-01T09:11:16Z
dc.date.issued2016
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionDyson, Paul/0000-0003-3117-3249; Therrien, Bruno/0000-0002-0388-2745; orhan, ersin/0000-0002-5461-1005en_US
dc.descriptionWOS: 000368090500006en_US
dc.description.abstractTetranuclear arene ruthenium complexes of the general formula [{Ru-2(p-cymene)(2)(mu(4)-L)}(2)(mu(4)-tpom)](4+) (tpom = tetrakis(4-pyridyloxymethylene)methane) were obtained from the corresponding dinuclear arene ruthenium complexes [Ru-2(p-cymene)(2)(m(4)-L)Cl-2] (L = diethyl-1,2-diazenedicarboxylato (dadc), oxalato (oxa), bis(2-hydroxyethyl)oxamidato (bho), bis{2-(2-hydroxyethoxy)ethyl}ethanediamidato (bhe), 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dihydroxy-3-phenyl-1,4-benzoquinonato (dhpb), 2,5-dibromo-1,4-benzoquinonato (dBrbq), 2,5-dioxido-3-undecyl-1,4-benzoquinonato (dubq), 2,5-dihydroxy-3,6-diphenyl-1,4-benzoquinonato (dhdb), 2,5-dihydroxy-3,6-(3,5-dimethylphenyl)-1,4-benzoquinonato (dhdm), 5,8-dioxido-1,4-naphtoquinonato (donq)) by reaction with the tetradentate tpom ligand and silver trifluoromethanesulfonate. The antiproliferative activity of the tetranuclear complexes was evaluated on cancerous (A2780 and A2780cisR) and non-cancerous (HEK293) cell lines, showing in most cases cancer cell selectivity and, in some cases, low micromolar cytotoxicities (similar to 1 mu M) against a cancer cell line that has acquired resistance to cisplatin. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipSwiss National Science FoundationSwiss National Science Foundation (SNSF) [200020_152552]; University of Neuchatelen_US
dc.description.sponsorshipFinancial support of this work by the Swiss National Science Foundation (grant 200020_152552) is gratefully acknowledged. E. O. thanks the Duzce University for a sabbatical leave and the University of Neuchatel for financial support.en_US
dc.identifier.doi10.1016/j.jorganchem.2015.12.013en_US
dc.identifier.endpage44en_US
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2015.12.013
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5453
dc.identifier.volume803en_US
dc.identifier.wosWOS:000368090500006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal Of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioorganometallic chemistryen_US
dc.subjectSupramolecular chemistryen_US
dc.subjectArene ruthenium complexesen_US
dc.subjectMetalla-assembliesen_US
dc.subjectMetal-based drugsen_US
dc.subjectHalf-sandwich complexesen_US
dc.titleCytotoxic double arene ruthenium metalla-cycles that overcome cisplatin resistanceen_US
dc.typeArticleen_US

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