Using Amino Acid-Silver Complexes Synthesized by Green Synthesis to Develop a New Antimicrobial Agent

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dc.authoridugras, halil ibrahim/0000-0002-1633-967Xen_US
dc.authoridKaragül, Bora/0000-0002-0834-6183en_US
dc.authoridugras, serpil/0000-0002-1867-5781en_US
dc.authorscopusid54397548800en_US
dc.authorscopusid58945428600en_US
dc.authorscopusid15136582600en_US
dc.authorscopusid58899822300en_US
dc.authorscopusid57200180817en_US
dc.authorscopusid6603474174en_US
dc.authorwosidugras, halil ibrahim/KSM-2767-2024en_US
dc.authorwosidKaragül, Bora/GRE-8901-2022en_US
dc.authorwosidugras, serpil/KSM-3256-2024en_US
dc.contributor.authorUgras, S.
dc.contributor.authorKaragul, P.
dc.contributor.authorRasgele, P. Goc
dc.contributor.authorYoldas, P. Agyar
dc.contributor.authorKaragul, B.
dc.contributor.authorUgras, H. I.
dc.date.accessioned2024-08-23T16:07:06Z
dc.date.available2024-08-23T16:07:06Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThe antimicrobial properties and importance of Ag+ have been known since ancient times. However, resistance has started to develop against silver ions, which are used indiscriminately and in high concentrations. Therefore, it is necessary to synthesize new and different silver complexes. In this study, five new molecules were synthesized by green synthesis from amino acids. Firstly, the antimicrobial activities of these molecules were tested with agar well diffusion assay. The result of this work is that it was revealed that the amino acid-silver complexes had very high inhibitory activity against microorganisms such as S. typhimirium, S. epidermidis, P. aeruginosa, K. pneumoniae, Y. pseudotuberculosis, P. vulgaris, E. faecalis, B. subtilis, E. cloaceae, S. aureus, E. coli, L. monocytogenes, C. albicans, and C. parapsilosis. It was found that these molecules have inhibition and bactericidal activity at low concentrations. The MIC, MBC, and MFC values were determined between 1.54-46.5 mu g/mL, 24.7-93.1 mu g/mL, and 19.0-197.0 mu g/mL, respectively. Then, to determine whether these molecules are suitable as antimicrobial agents, cytotoxic and antimutagenic activity tests were performed. The results of the cytotoxicity test showed that these molecules have no cytotoxic effect on the L929 fibroblast cells except some at higher doses (e.g. 10-100 mg/mL). In addition, cell viability stimulation was recorded at some doses below 10 mg/mL. Furthermore, these molecules showed antimutagenic activity at different concentrations 1.17-5.80 mu g/mL. The use of these synthesized molecules as antimicrobial agents in many fields such as food and pharmacology seems very promising.en_US
dc.identifier.doi10.1007/s11094-024-03075-4
dc.identifier.endpage1753en_US
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85188117353en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1745en_US
dc.identifier.urihttps://doi.org/10.1007/s11094-024-03075-4
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14494
dc.identifier.volume57en_US
dc.identifier.wosWOS:001186743000004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantimicrobial agenten_US
dc.subjectamino acid silver saltsen_US
dc.subjectantimicrobial activityen_US
dc.subjectames assayen_US
dc.subjectantimutagenicityen_US
dc.subjectAntibacterial Activityen_US
dc.subjectNanoparticlesen_US
dc.subjectNitrateen_US
dc.subjectIonen_US
dc.titleUsing Amino Acid-Silver Complexes Synthesized by Green Synthesis to Develop a New Antimicrobial Agenten_US
dc.typeArticleen_US

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