Protective Effects of Ellagic Acid Against Chemotherapy-Induced Hepatotoxicity

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dc.contributor.authorYalçın, Alper
dc.contributor.authorKeleş, Hikmet
dc.contributor.authorAydın, Hasan
dc.contributor.authorBozkurt, Mehmet Fatih
dc.contributor.authorKahraman, Tahir
dc.date.accessioned2023-04-10T20:19:31Z
dc.date.available2023-04-10T20:19:31Z
dc.date.issued2020
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: Cyclophosphamide (CP) is a commonly used chemotherapeutic agent despite its toxicadverse effects, including hepatotoxicity. Ellagic acid (EA) is an antioxidant agent and exhibitsfree radical scavenging activities. In this experimental study, the effects of EA on CP-inducedliver injury were investigated.Material and Methods: Twenty-four Sprague-Dawley rats (180-220 gr) were separated intofour equal groups. A single dose of 150 mg/kg CP was given intraperitoneally to generatehepatotoxicity. Different doses (50 and 75 mg/kg) of EA were administered orally 20 minutesbefore, 4 and 8 hours after CP administration. The histopathological evaluation of kidneytissues and immunohistochemical evaluation for caspase-3 were conducted as well as theserum biochemical analyses.Results: CP treated group exhibited a significant increase in serum hepatic enzymes, aspartateaminotransferase (AST) and alanine aminotransferase (ALT), compared to the control group.Similarly, the total triglycerides (TG) and very-low-density lipoprotein cholesterol (VLDL-C)levels increased significantly. Additionally, the high-density lipoprotein cholesterol (HDL-C)levels decreased, which was not significant, compared to the control group. At both EA doses,VLDL-C, AST, ALT levels decreased significantly while HDL-C level revealed a significantincrease. 75 mg/kg EA treatment caused a non-significant elevation in total cholesterol (TC)concentration. Microscopic analysis showed a significant congestion, edema, degeneration andnecrosis in the livers of CP administered group. However, edema, degeneration, and necrosiswere significantly reduced in animals treated with EA-75. In addition, caspase-3 expressionsignificantly decreased in EA-75 group.Conclusion: These results indicate the protective effects of EA in CP-induced hepatotoxicity in rats.en_US
dc.identifier.doi10.18678/dtfd.748816
dc.identifier.endpage130en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.startpage124en_US
dc.identifier.trdizinid385820en_US
dc.identifier.urihttp://doi.org/10.18678/dtfd.748816
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/385820
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11395
dc.identifier.volume22en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleProtective Effects of Ellagic Acid Against Chemotherapy-Induced Hepatotoxicityen_US
dc.typeArticleen_US

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