The protective effect of docosahexaenoic acid on the stomach in Parkinson's disease induced by MPTP in male C57BL/6 mice

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dc.authoridBIRSEN, ILKNUR/0000-0002-8637-0250
dc.authorwosidSoylu, Hakan/I-8911-2017
dc.authorwosidParlak, Hande/GLN-2748-2022
dc.contributor.authorBirsen, İlknur
dc.contributor.authorAvci, Sema
dc.contributor.authorIzgut-Uysal, V. Nimet
dc.contributor.authorSoylu, Hakan
dc.contributor.authorÖzkan, Ayşe
dc.contributor.authorParlak, Hande
dc.contributor.authorAcar, Nuray
dc.date.accessioned2023-07-26T11:50:24Z
dc.date.available2023-07-26T11:50:24Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractThe purpose of this study was to detect gastric changes in Parkinson's disease induced by 1-methyl-4-phenyl-1.2.3.6.-tetrahydropyridine (MPTP), and to investigate the protective effect of docosahexaenoic acid (DHA) against these changes in mice. The mice were divided into 4 groups (n=10 in per group) as control, DHA, Parkinson and DHA+Parkinson groups. DHA was administered by gavage for 30 days. On the 23th day of gavage treatment, the animals of the Parkinson and DHA+Parkinson groups were intraperitoneally injected with MPTP. Seven days after the injection of MPTP, their locomotor activity, bradykinesia and rotarod performance were measured. Tyrosine hydroxylase expression in substantia nigra and the apoptotic index, the concentrations of tumor necrosis factor-alpha and histamine, and the number of mast cells in the stomach were evaluated. Administration of DHA significantly prevented the reduction in motor functions (P<0.001) and nigral TH neurons (P<0.05), and apoptosis (P<0.05), and an increase in TNF-alpha concentration (P<0.01) in the stomach. An increase in the number of mast cells in the stomach wall was observed in PD (P<0.001). DHA prevented the increase in the number of mast cells (P<0.05) and the histamine level (P<0.01) due to PD. As a result, MPTP administration in mice caused changes in the stomach as well as impairment in motor functions, and DHA was observed to reduce these changes.en_US
dc.description.sponsorshipAkdeniz University Research Projects Unit [2013.02.0122.012]en_US
dc.description.sponsorshipThis study was supported by the Akdeniz University Research Projects Unit (Project number: 2013.02.0122.012) .en_US
dc.identifier.doi10.24099/vet.arhiv.1368
dc.identifier.endpage192en_US
dc.identifier.issn0372-5480
dc.identifier.issn1331-8055
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85131597967en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://doi.org/10.24099/vet.arhiv.1368
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12340
dc.identifier.volume92en_US
dc.identifier.wosWOS:000798494200008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorSoylu, Hakan
dc.language.isoenen_US
dc.publisherUniv Zagreb Vet Facultyen_US
dc.relation.ispartofVeterinarski Arhiven_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectDocosahexaenoic Acid; Gastric Tissue; Mptp; Apoptosis; Mast Cells; Miceen_US
dc.subjectMouse Model; 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mptp; Rat Model; Mechanism; Apoptosis; Roles; Brain; Risk; Dhaen_US
dc.titleThe protective effect of docosahexaenoic acid on the stomach in Parkinson's disease induced by MPTP in male C57BL/6 miceen_US
dc.title.alternativezaštitni u?inak dokozaheksaenske kiseline na ?eludac muških c57Bl/6 miševa s Parkinsonovom boleš?u izazvanom s MPTPen_US
dc.typeArticleen_US

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