In vitro bacterial adherence to teicoplanin and calcium sulfate-soaked bone cement

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dc.contributor.authorŞencan, İrfan
dc.contributor.authorŞahin, İdris
dc.contributor.authorTüzüner, Tolga
dc.contributor.authorÖzdemir, Davut
dc.contributor.authorYıldırım, Mustafa
dc.contributor.authorLeblebicioğlu, Hakan
dc.date.accessioned2020-04-30T23:18:27Z
dc.date.available2020-04-30T23:18:27Z
dc.date.issued2005
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionLeblebicioglu, Hakan/0000-0002-6033-8543en_US
dc.descriptionWOS: 000229303900007en_US
dc.descriptionPubMed: 15920902en_US
dc.description.abstractThe aim of this study was to assess in vitro the improvement in release kinetics for teicoplanin and the inhibition of bacterial adhesion on calcium sulfate-soaked PMMA discs. Calcium sulfate has been used in vivo and shown to be biocompatible, and prevention of bacterial adhesion may be expected with calcium sulfate-soaked polymethylmethacrylate (PMMA). Discs were made by adding teicoplanin and calcium sulfate in powder form to PMMA powder. The antibiotic concentration eluted from PMMA discs was assayed by agar diffusion assay. Nonadherent bacteria were removed by washing and adherent bacteria were detached by sonication. The suspension including nonadherent bacteria was seeded on sheep blood agar plate and incubated for 24 h at 37 degrees C for the growth of microorganisms. The teicoplanin released from discs containing calcium sulfate was higher than that released from discs which had not been soaked with calcium sulfate. The count of bacteria adhering to the calcium sulfate-soaked discs was lower than that from the discs without calcium sulfate. In conclusion, the addition of calcium sulfate to teicoplanin-loaded PMMA bone cement may provide local antibiotic concentrations higher than MIC values due to increased antibiotic release. Furthermore, calcium sulfate was found to be effective in reducing bacterial adherence to treated discs.en_US
dc.identifier.doi10.1179/joc.2005.17.2.174en_US
dc.identifier.endpage178en_US
dc.identifier.issn1120-009X
dc.identifier.issue2en_US
dc.identifier.startpage174en_US
dc.identifier.urihttps://doi.org/10.1179/joc.2005.17.2.174
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3324
dc.identifier.volume17en_US
dc.identifier.wosWOS:000229303900007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE I F T Srlen_US
dc.relation.ispartofJournal Of Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbone cementen_US
dc.subjectcalciumen_US
dc.subjectadhesionen_US
dc.subjectteicoplaninen_US
dc.titleIn vitro bacterial adherence to teicoplanin and calcium sulfate-soaked bone cementen_US
dc.typeArticleen_US

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