Preparation of Centella asiatica (L.) and Hypericum perforatum (St. John's Wort) Plant Extracts and Development of Anti-Aging Herbal Cream Formulations
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Tarih
2023
Yazarlar
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The study aims to use two different plant extracts, St. John's Wort (Hypericum perforatum) and Centella asiatica (L.), in the cream formulation and determine the new formulation's anti-aging effect. Materials-Methods: The plants used in the study were obtained commercially, and plant extracts were obtained using the classical extraction techniques in the literature. The active ingredients in the obtained extracts were determined by the HPLC method. Physical, protective efficacy, microbial analysis, and anti-aging tests were carried out for cream formulations obtained with extracts. Results: Plant extraction studies were carried out in the study. Centella asiatica (L.) was extracted with a 20.8% yield at 20 mL of methanol and 60?. As a result of HPLC analysis, it was determined that there were 1740 mg/kg asiatic acid and 4380 mg/kg madecasic acid in the extract. In the extraction studies performed on Hypericum perforatum, the expected active ingredient, hypericin, was not found. For this reason, a commercial extract containing 2.5% hyperforin was obtained, and the studies were continued on these extracts, and final cream formulations were obtained. Conclusion: pH, viscosity, density, protective effectiveness tests, and microbial analysis tests of the final formulations were performed. In addition, in vitro, anti-aging studies have been carried out in accredited laboratories. In-vitro anti-aging tests determined that the level of collagen 1A increased more in the formulation where both extracts were used together.
Açıklama
Anahtar Kelimeler
Kaynak
International journal of traditional and complementary medicine research (Online)
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Scopus Q Değeri
Cilt
4
Sayı
2
