Serum folate is associated with coronary heart disease independently of homocysteine in Turkish men

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dc.contributor.authorOnat, Altan
dc.contributor.authorHergenç, Gülay
dc.contributor.authorKüçükdurmaz, Zekeriya
dc.contributor.authorCan, Günay
dc.contributor.authorAyhan, Erkan
dc.contributor.authorBulur, Serkan
dc.date.accessioned2020-04-30T23:31:52Z
dc.date.available2020-04-30T23:31:52Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000261016000009en_US
dc.descriptionPubMed: 18694616en_US
dc.description.abstractBackground Et aims: Whether serum homocysteine levels are associated with coronary heart disease (CHD) and the metabolic syndrome (MS) needs investigation in different ethnic groups. These associations and the influence of serum folate and vitamin 1312 thereupon were addressed separately in genders. Methods: A random sample of Turkish adults was studied cross-sectionally. Results: Median age of 338 men and 342 women was 55 years. Geometric mean serum homocysteine concentrations were 12.7 +/- 1.5 mu mol/l in men and 9.6 +/- 1.4 mu mol/l in women (p < 0.001). Linear regression analysis among 11 variables revealed mate sex, reduced estimated glomerular filtration rate (eGFR) and vitamin B-12, (in men) reduced folate as significant independent covariates of higher homocysteine levels. Logistic regression analysis disclosed that (sex-specific) top versus bottom homocysteine tertile was borderline significantly and independently associated with CHD in men and both genders combined, after adjustment for gender, age, smoking status, systolic blood pressure, eGFR, folate and vit B-12. Folate revealed significant inverse association with CHD likelihood in men and combined genders (OR 0.73 for doubling [95%CI 0.56; 0.94]), independently of homocysteine levels and even of presence of type-2 diabetes. Serum vit B-12 concentrations were significantly associated with MS likelihood in women atone after adjustment for sex, age, smoking status, folate and antidiabetic medication. Conclusion: High serum homocysteine and tow folate levels are associated in Turkish men independently with CHD, which needs confirmation in a larger sample. In women, vitamin B-12 concentrations are significantly associated with MS likelihood. (C) 2008 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.en_US
dc.description.sponsorshipTurkish Society of Cardiology; Pharmaceutical and Nutritional Companies AstraZeneca, Pfizer, SanofiAventis, Novartis and, Danone, Istanbul, TurkeySanofi-AventisPfizeren_US
dc.description.sponsorshipWe thank the Turkish Society of Cardiology and the pharmaceutical and nutritional companies AstraZeneca, Pfizer, SanofiAventis, Novartis and, Danone, Istanbul, Turkey, that have supported financially the Turkish Adult Risk Factor survey 2005-07. We appreciate the dedicated works of A.M. Esen, MD; H. Uyarel, MD; A. Karabulut, MD; Z. Kaya and Mr. M. Ozmay, the coworkers in the survey teams.en_US
dc.identifier.doi10.1016/j.clnu.2008.06.009en_US
dc.identifier.endpage739en_US
dc.identifier.issn0261-5614
dc.identifier.issn1532-1983
dc.identifier.issue5en_US
dc.identifier.startpage732en_US
dc.identifier.urihttps://doi.org/10.1016/j.clnu.2008.06.009
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4505
dc.identifier.volume27en_US
dc.identifier.wosWOS:000261016000009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofClinical Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary heart diseaseen_US
dc.subjectFolateen_US
dc.subjectHomocysteineen_US
dc.subjectMetabolic syndromeen_US
dc.subjectVitamin B-12en_US
dc.titleSerum folate is associated with coronary heart disease independently of homocysteine in Turkish menen_US
dc.typeArticleen_US

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