A new approach to prealbumin as a biomarker for fibromyalgia?

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dc.contributor.authorKarabacak, Elif
dc.contributor.authorYayla, Muhtesem E.
dc.contributor.authorOzturk, Gulsah Y.
dc.contributor.authorOzelbaykal, Bahadir
dc.date.accessioned2025-10-11T20:47:37Z
dc.date.available2025-10-11T20:47:37Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractAims. Fibromyalgia (FM) is a chronic, widespread musculoskeletal disease that is usually accompanied by hyperalgesia, fatigue, sleep disturbance and depression. Although the etiopathogenesis of this syndrome is unclear, it is presumed to have an inflammatory basis.There are currently no laboratory markers available to diagnose the condition.The aim of this study was to investigate potential biochemical markers that would prove to be valid, simple, routinely used, quickly and cheaply studied and obtainable in blood count tests. Methods. 46 patients diagnosed with FM according to ACR (American College of Rheumatology) 2010 diagnostic criteria and 35 patients as a healthy control group were included in the study. Prealbumin, complete blood count, sediment and C-reactive protein (CRP) values of FM and control group patients were examined. Additionally, Hospital Anxiety and Depression Scale, Jenkins Sleep Scale and the Fibromyalgia Impact Questionnaire (FIQ) were administered to patients diagnosed with FM. Results.There was a significant difference between fibromyalgia patients and control groups in terms of prealbumin, platelet, CRP, CRP/prealbumin and lymphocyte parameters (P=0.048, P=0.046, P<0.001, P=0.003 and P<0.001, respectively). Only a weak positive correlation was found between CRP and FIQ (rS =0.309, P=0.037, CI=0.012-0.556). Conclusion. The serum levels of some tested markers, including platelets, CRP, CRP/prealbumin and lymphocytes, were significantly higher and prealbumin was lower in patients with FM than in the control group, suggesting they could be valid in fibromyalgia diagnosis. The CRP level may be informative about the severity of the FM and it may play a role in the inflammation possibly underlying the pathogenesis of FM.en_US
dc.identifier.doi10.5507/bp.2025.014
dc.identifier.issn1213-8118
dc.identifier.issn1804-7521
dc.identifier.pmid40384372en_US
dc.identifier.urihttps://doi.org/10.5507/bp.2025.014
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21476
dc.identifier.wosWOS:001504528800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPalacky Univ, Medical Facen_US
dc.relation.ispartofBiomedical Papers-Olomoucen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectCRPen_US
dc.subjectCRP/prealbuminen_US
dc.subjectlymphocyteen_US
dc.subjectplateleten_US
dc.subjectprealbuminen_US
dc.titleA new approach to prealbumin as a biomarker for fibromyalgia?en_US
dc.typeArticleen_US

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