Comparison of hippocampus, entorhinal cortex, and amygdala volumes in individuals with Alzheimer's disease, mild cognitive impairment, and healthy individuals

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dc.contributor.authorSenol, Deniz
dc.contributor.authorSecgin, Yusuf
dc.contributor.authorKaya, Seren
dc.contributor.authorOzturk, Oguzhan
dc.contributor.authorHarmandaoglu, Oguzhan
dc.date.accessioned2026-07-01T11:39:40Z
dc.date.available2026-07-01T11:39:40Z
dc.date.issued2026
dc.departmentDüzce Üniversitesi
dc.description.abstractBackground: Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are associated with structural alterations in medial temporal lobe regions, which can be evaluated using volumetric magnetic resonance imaging. Objective: In this study, we aimed to compare the volumes of the hippocampus, amygdala, and entorhinal cortex in individuals diagnosed with MCI and AD with those of healthy controls. Methods: Magnetic resonance images from AD, MCI, and healthy control groups were retrospectively obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, including 100 individuals in each group. Volumetric measurements of the right, left, and total hippocampus, amygdala, and entorhinal cortex, as well as their ratios to total brain volume, were obtained using the VolBrain automated segmentation software. Results: The volumes of the hippocampus, amygdala, and entorhinal cortex were significantly lower in the AD group compared with both the MCI and control groups (p < 0.05). In comparisons between the MCI and control groups, a statistically significant difference was observed only in the left entorhinal cortex volume, whereas no significant differences were detected in other medial temporal structures. Conclusions: These findings demonstrate group-level differences in medial temporal lobe volumes, with more pronounced reductions observed in individuals with AD. The isolated reduction observed in the left entorhinal cortex in the MCI group reflects a region-and hemisphere-specific structural difference at the group level, which should be interpreted cautiously and warrants further investigation using longitudinal and clinico-cognitive approaches.
dc.identifier.doi10.1177/13872877261450574
dc.identifier.issn1387-2877
dc.identifier.issn1875-8908
dc.identifier.orcid0000-0002-4991-5696
dc.identifier.orcid0000-0001-7518-0331
dc.identifier.pmid42115829
dc.identifier.urihttps://doi.org/10.1177/13872877261450574
dc.identifier.urihttps://hdl.handle.net/20.500.12684/23421
dc.identifier.wosWOS:001763725000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal of Alzheimers Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260623
dc.subject[Keyword Not Available]
dc.titleComparison of hippocampus, entorhinal cortex, and amygdala volumes in individuals with Alzheimer's disease, mild cognitive impairment, and healthy individuals
dc.typeArticle

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