Bioactivity of non-extractable phenolics from lemon peel obtained by enzyme and ultrasound assisted extractions

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dc.authorscopusid57222085013en_US
dc.authorscopusid7006429535en_US
dc.contributor.authorDurmus, Nihal
dc.contributor.authorKilic-Akyilmaz, Meral
dc.date.accessioned2024-08-23T16:04:46Z
dc.date.available2024-08-23T16:04:46Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractLemon peel waste constitutes a natural resource for bioactive phenolics with antioxidant, antihypertensive and antidiabetic activities. Bioactivities of non-extractable phenolics from lemon peel obtained by conventional heat-, enzyme-, ultrasound-, and ultrasound-enzyme-assisted extractions were evaluated in comparison with those of extractable phenolics. The antioxidant, angiotensin-I-converting enzyme (ACE), and alpha-amylase inhibitory ac-tivities and phenolic profile of the phenolic fractions were analysed. While the extractable fraction had higher total phenolic content, ascorbic acid content, and antioxidant activity, phenolic profile analysis indicated that the non-extractable fraction contained higher concentrations of phenolics especially hesperidin and hesperetin. The concentrations of hesperidin and hesperetin in the non-extractable fraction were 270.9 mg/100 g dry weight and 415.9 mg/100 g dry weight, respectively, which were about two-fold higher than those present in the extractable fraction. Moreover, ACE and alpha-amylase inhibitory activities of non-extractable fraction were stronger than those of the extractable fraction. Total phenolic content, total flavonoid content, and antioxidant activity were increased by enzyme and ultrasound treatments compared to those by conventional heat treatment. However, ACE inhibitory activities of all non-extractable fractions were similar while alpha-amylase inhibitory activity was higher in ultrasound-and ultrasound-enzyme-treated fractions. While ultrasound-assisted extraction slightly improved the yield of non-extractable phenolics, enzyme-assisted extraction yielded two-to four-fold increases in the amounts of phenolic compounds compared to heat-assisted extraction. Non-extractable phenolic fraction from lemon peel was found to have a significant potential as an antihypertensive and antidiabetic agent.en_US
dc.description.sponsorshipIstanbul Technical University Scientific Research Fund [MDK- 2020-42448]en_US
dc.description.sponsorshipThis research was financially supported by the Istanbul Technical University Scientific Research Fund with a project number of MDK- 2020-42448.en_US
dc.identifier.doi10.1016/j.fbio.2023.102571
dc.identifier.issn2212-4292
dc.identifier.issn2212-4306
dc.identifier.scopus2-s2.0-85151069253en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2023.102571
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14357
dc.identifier.volume53en_US
dc.identifier.wosWOS:000966440800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofFood Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLemon peel wasteen_US
dc.subjectUltrasounden_US
dc.subjectEnzymeen_US
dc.subjectAngiotensin-I-Converting enzymeen_US
dc.subject?-Amylaseen_US
dc.subjectAntioxidant Activityen_US
dc.subjectBy-Productsen_US
dc.subjectVitamin-Cen_US
dc.subjectConverting-Enzymeen_US
dc.subjectAlpha-Glucosidaseen_US
dc.subjectBound Phenolicsen_US
dc.subjectAscorbic-Aciden_US
dc.subjectCitrusen_US
dc.subjectPolyphenolsen_US
dc.subjectFlavonoidsen_US
dc.titleBioactivity of non-extractable phenolics from lemon peel obtained by enzyme and ultrasound assisted extractionsen_US
dc.typeArticleen_US

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