Castor oil-based graft copolymers: synthesis, characterization antimicrobial activity and antiproliferative effects against breast cancer cell lines

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dc.contributor.authorAllı, Sema
dc.contributor.authorDülger, Görkem
dc.contributor.authorKılıççıoğlu, İlker
dc.contributor.authorAllı, Abdulkadir
dc.contributor.authorDülger, Başaran
dc.date.accessioned2023-07-26T11:53:51Z
dc.date.available2023-07-26T11:53:51Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.description.abstractCastor oil was autoxidized for three months to obtain macroperoxide castor oil (PCO). Since this polymeric oil has peroxide groups and hydroxyl groups, free-radical polymerization (FRP), ring-opening polymerization, and one-pot polymerization both free-radical polymerization (FRP) and ring-opening polymerization in one step methods were used to synthesis of various types of the graft copolymers. PCO-g-Polystyrene, PCO-g-Poly(methyl acrylate), and PCO-g-Poly(tert-buytl acrylate) were synthesized using the free-radical polymerization method. PCO-g-Poly(epsilon-caprolactone) graft copolymer was obtained via ring-opening polymerization, and PCO-g-Polystyrene-g-Poly(epsilon-caprolactone) graft copolymer was obtained using one-pot polymerization method. All graft copolymers obtained were characterized by proton nuclear magnetic resonance (H-1 NMR), Fourier-transform infrared, differential scanning calorimetry, thermal gravimetric analysis, and elemental analysis. After the synthesis of castor oil-based copolymers, we determined the antimicrobial effects of them as well as the antiproliferative effects on breast cancer cell lines. Antimicrobial activity was carried out using the disc diffusion method and the dilution method. As a result of antimicrobial activity, the compounds showed moderate antimicrobial effects on microorganisms compared to standard antibiotics. In particular, the compounds have shown more antibacterial activity than antifungal activity. We also observed a prominent antiproliferative effect of synthesized compounds depending on increasing doses (1-25 mu g/mL) and times (24-48 h) in MDA-MB-231 breast cancer cells.en_US
dc.description.sponsorshipDuzce University Research Funds [2020.05.03.1134, 2020.05.03.1135, 2021.05.03.1176]en_US
dc.description.sponsorshipThis work was supported by the Duzce University Research Funds (2020.05.03.1134, 2020.05.03.1135, 2021.05.03.1176)en_US
dc.identifier.doi10.1007/s00289-021-03908-2
dc.identifier.endpage11199en_US
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85123124933en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage11177en_US
dc.identifier.urihttps://doi.org/10.1007/s00289-021-03908-2
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12632
dc.identifier.volume79en_US
dc.identifier.wosWOS:000742256500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAllı, Sema
dc.institutionauthorAllı, Abdulkadir
dc.institutionauthorDülger, Görkem
dc.institutionauthorKılıççıoğlu, İlker
dc.institutionauthorBaşaran, Dülger
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPolymer Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAutoxidation; Castor Oil; Graft Copolymer; Antimicrobial; Antiproliferative; Breast Canceren_US
dc.subjectAciden_US
dc.titleCastor oil-based graft copolymers: synthesis, characterization antimicrobial activity and antiproliferative effects against breast cancer cell linesen_US
dc.typeArticleen_US

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