Effects of Some Adsorbents on the Pre-purification of Taxol (Anticancer Drug) from Hazelnut Nutshells

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dc.contributor.authorOğuzkan, Sibel Bayıl
dc.contributor.authorKaradeniz, Şeref
dc.contributor.authorKaragül, Bora
dc.contributor.authorUzun, Ayşe
dc.contributor.authorAksoy, Elif Sine
dc.contributor.authorGüler, Özen Özensoy
dc.contributor.authorUğraş, Halil İbrahim
dc.date.accessioned2020-05-01T09:12:03Z
dc.date.available2020-05-01T09:12:03Z
dc.date.issued2018
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionoguzkan, sibel Bayil/0000-0003-0254-6915en_US
dc.descriptionWOS: 000438908200011en_US
dc.description.abstractBackground and Objective: The most important pharmaceutically active substance in plant-derived chemotherapy drugs is paclitaxel. Taxane compounds such as paclitaxel, cephalomannine, baccatin III and 10-Deacetylbaccatin III are found in hazelnut shells of Turkey's Black Sea region. This study aimed to determine the most effective adsorbent on the purity and efficiency of these taxane compounds from nutshells. Materials and Methods: The adsorbent effect on the purification of taxane compounds from hazelnut shells was studied using different adsorbent materials. For this purpose, extracts were obtained from samples of hazelnut shells collected, dried and ground into solvents. The resulting extract was concentrated into a stock solution. Samples taken from the stock solution were separately treated with seven different adsorbent materials and then filtered and analyzed with HPLC (High Performance Liquid Chromatography). Results: The HPLC analysis of taxane compounds determined on taxane, both the purification and whether or not the substance was lost, by measuring the efficiency at the same time. Graphene-oxide was found to be the adsorbent with the highest positive effect on the purification of paclitaxel in hazelnut nutshells in all cases. Graphene-oxide also had the least loss in terms of paclitaxel yield efficiency in hazelnut nutshells. Conclusion: The effects of adsorbent treatment increased both the purity and efficiency of taxane compounds and was, thus, a useful pre-purification method for shells obtained from Turkish hazelnuts. This shell waste material may prove to be a good alternative source of taxol as an anticancer drug.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK-114Z233]en_US
dc.description.sponsorshipThe authors express great thanks to the Scientific and Technological Research Council of Turkey for its financial support (TUBITAK-114Z233 coded project).en_US
dc.identifier.doi10.3923/ijp.2018.835.840en_US
dc.identifier.endpage840en_US
dc.identifier.issn1811-7775
dc.identifier.issn1812-5700
dc.identifier.issue6en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage835en_US
dc.identifier.urihttps://doi.org/10.3923/ijp.2018.835.840
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5860
dc.identifier.volume14en_US
dc.identifier.wosWOS:000438908200011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAsian Network Scientific Information-Ansineten_US
dc.relation.ispartofInternational Journal Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHazelnut shellsen_US
dc.subjectgraphene-oxideen_US
dc.subjectadsorbenten_US
dc.subjectpaclitaxelen_US
dc.subject10-Deacetylbaccatin IIIen_US
dc.titleEffects of Some Adsorbents on the Pre-purification of Taxol (Anticancer Drug) from Hazelnut Nutshellsen_US
dc.typeArticleen_US

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