The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in the Emergency Department
dc.contributor.author | Küçükceran, Kadir | |
dc.contributor.author | Yılmaz, Sibel İba | |
dc.contributor.author | Karaşahin, Ömer | |
dc.contributor.author | Batur, Ali | |
dc.contributor.author | Delice, Orhan | |
dc.contributor.author | Şebin, Engin | |
dc.contributor.author | Şenyurt, Mahmut | |
dc.date.accessioned | 2023-04-10T20:19:34Z | |
dc.date.available | 2023-04-10T20:19:34Z | |
dc.date.issued | 2021 | |
dc.department | Rektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergileri | en_US |
dc.description.abstract | Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor(urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed onvarious cell types. Previous literature shows that the amount of soluble urokinase-typeplasminogen activator receptor (suPAR) secreted from affected cells is higher in Crimean-Congohemorrhagic fever (CCHF) patients than in healthy controls. Thus, we aimed to investigate thediagnostic value of suPAR in the differential diagnosis of CCHF in emergency services.Material and Methods: Individuals over 16 years old with a preliminary diagnosis of CCHFdisease were divided into two groups as real time-polymerase chain reaction (RT-PCR) and/orIgM positive (CCHF group) and RT-PCR and/or IgM negative (control group).Results: Eighty patients were included in this study. Forty patients with CCHF virus PCRand/or CCHF virus IgM were identified as CCHF group and 40 patients included as negativecontrol group. The median age of the patients was 45 (range, 16-91) years, and 49 patients(61.3%) were male. Leukocyte, platelet, and fibrinogen levels were significantly lower, whilecreatinine kinase, aPTT, and D-dimer levels were significantly higher in CCHF group. Therewas no statistically significant difference between the control group and CCHF group forSuPAR (p=0.386). In addition, control group patients not diagnosed with CCHF wereexamined, brucellosis, influenza, and pneumonia were found to be the most common.Conclusion: The use of suPAR as a biomarker in the differentiation of patients with similarfindings in emergency services was investigated and found to have no diagnostic value. | en_US |
dc.identifier.doi | 10.18678/dtfd.820602 | |
dc.identifier.endpage | 19 | en_US |
dc.identifier.issn | 1307-671X | |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 15 | en_US |
dc.identifier.trdizinid | 421859 | en_US |
dc.identifier.uri | http://doi.org/10.18678/dtfd.820602 | |
dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/421859 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12684/11416 | |
dc.identifier.volume | 23 | en_US |
dc.indekslendigikaynak | TR-Dizin | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Düzce Tıp Fakültesi Dergisi | en_US |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in the Emergency Department | en_US |
dc.type | Article | en_US |
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