The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in the Emergency Department

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dc.contributor.authorKüçükceran, Kadir
dc.contributor.authorYılmaz, Sibel İba
dc.contributor.authorKaraşahin, Ömer
dc.contributor.authorBatur, Ali
dc.contributor.authorDelice, Orhan
dc.contributor.authorŞebin, Engin
dc.contributor.authorŞenyurt, Mahmut
dc.date.accessioned2023-04-10T20:19:34Z
dc.date.available2023-04-10T20:19:34Z
dc.date.issued2021
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor(urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed onvarious cell types. Previous literature shows that the amount of soluble urokinase-typeplasminogen activator receptor (suPAR) secreted from affected cells is higher in Crimean-Congohemorrhagic fever (CCHF) patients than in healthy controls. Thus, we aimed to investigate thediagnostic value of suPAR in the differential diagnosis of CCHF in emergency services.Material and Methods: Individuals over 16 years old with a preliminary diagnosis of CCHFdisease were divided into two groups as real time-polymerase chain reaction (RT-PCR) and/orIgM positive (CCHF group) and RT-PCR and/or IgM negative (control group).Results: Eighty patients were included in this study. Forty patients with CCHF virus PCRand/or CCHF virus IgM were identified as CCHF group and 40 patients included as negativecontrol group. The median age of the patients was 45 (range, 16-91) years, and 49 patients(61.3%) were male. Leukocyte, platelet, and fibrinogen levels were significantly lower, whilecreatinine kinase, aPTT, and D-dimer levels were significantly higher in CCHF group. Therewas no statistically significant difference between the control group and CCHF group forSuPAR (p=0.386). In addition, control group patients not diagnosed with CCHF wereexamined, brucellosis, influenza, and pneumonia were found to be the most common.Conclusion: The use of suPAR as a biomarker in the differentiation of patients with similarfindings in emergency services was investigated and found to have no diagnostic value.en_US
dc.identifier.doi10.18678/dtfd.820602
dc.identifier.endpage19en_US
dc.identifier.issn1307-671X
dc.identifier.issue1en_US
dc.identifier.startpage15en_US
dc.identifier.trdizinid421859en_US
dc.identifier.urihttp://doi.org/10.18678/dtfd.820602
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/421859
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11416
dc.identifier.volume23en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in the Emergency Departmenten_US
dc.typeArticleen_US

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