Anormal uterin kanamalı hastalarda endometrium kanseri ve benign endometrial patoloji tanısı alanların hematolojik parametrelerinin karşılaştırılması
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Dosyalar
Tarih
2014
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Cilt Başlığı
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Çalışmamızın amacı 40 yaş ve üstünde anormal uterin kanama (AUK) şikayeti bulunan hastalarda evre 1 ve evre 2 endometrium kanseri tanısı alanlar ile benign endometrial patoloji tanısı alanların ortalama trombosit hacmi (MPV), nötrofil/lenfosit oranı (NLR) ve trombosit/lenfosit oranı (PLR) değerlerini karşılaştırmaktır. Yöntem: Çalışmamıza Temmuz 2012-Temmuz 2013 tarihleri arasında Düzce Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı’na AUK ön tanısıyla histeroskopi, dilatasyon küretaj yada endometrial biopsi ile endometrial örnekleme yapılan hastalar dahil edilmiştir. Hastalara ait bilgiler retrospektif olarak hasta dosyaları incelenerek elde edilmiştir. Bulgular: Hastaların ortalama yaşı 52.8111.47 yıl olarak bulunmuştur. Hastaların %37.1’si menopozdadır. Yapılan endometrial örneklemelerin sonucunda hastalardan 10 tanesinde (%14.2) endometrioid tip endometrial adenokarsinom, 1 tanesinde (%1.4) seröz papiller karsinom ve 1 tanesinde (%1.4) endometrial stromal sarkom tanısı konulmuştur. Hastaların 58 (%83) tanesinde non invaziv benign endometrial değişiklikler tespit edilmiştir. Endometrium kanseri saptanan ve saptanmayan hastalar arasında MPV,NLR ve PLR değerleri açısından istatistiksel olarak anlamlı farklılık tespit edilmemiştir (p0.148; p0.775 ve p0.942 sırasıyla). Sonuç: MPV, NLR ve PLR değerlerinin ileri evre endometrial malignitelerde yükseldiği ve prognostik bir faktör olarak kullanılabileceği bazı çalışmalarda gösterilmiştir. Ancak bu parametrelerin erken evre endometrium kanseri ve benign endometrial patoloji tespit edilen hastalar arasında gösterdiği değişimlerin net olarak ortaya konabilmesi için geniş kapsamlı yeni çalışmalara gerek duyulmaktadır.
Aim: The aim of this study is to compare the mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR) and platelets/lymphocyte ratio (PLR) in patients with abnormal uterine bleeding (AUB) aged 40 years or more with a diagnosis of endometrial cancer stage 1-2 and benign endometrial pathology. Materials and Methods: The patients with AUB who underwent hysteroscopy, dilatation curettage, or endometrial biopsy between July 2012 and July 2013 were included. All data was achieved by examining inpatient medical records retrospectively. Results: The mean age of patients was 52.81±11.47 years. 37.1% of the patients was at menopause. Endometrioid endometrial adenocarcinoma diagnosed in 10 patients (14.2%), papillary serous carcinoma in 1 patient (1.4%) and endometrial stromal sarcoma in 1 patient (1.4%). Non-invasive benign endometrial histological changes were identified in 58 patients (83%). There was no statistically significant difference between the patients with endometrium cancer and without endometrium cancer in terms of MPV, NLR and PLR values (p0.148, p 0.775 and p0.942, respectively). Conclusions: It has been shown in some studies that MPV, NLR and PLR values increase with advanced stage endometrial malignancies and can be used as prognostic factor. However, in order to clearly identify the alternation of these parameters between patients with early-stage endometrial carcinoma and benign endometrial pathology new and comprehensive studies are needed.
Aim: The aim of this study is to compare the mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR) and platelets/lymphocyte ratio (PLR) in patients with abnormal uterine bleeding (AUB) aged 40 years or more with a diagnosis of endometrial cancer stage 1-2 and benign endometrial pathology. Materials and Methods: The patients with AUB who underwent hysteroscopy, dilatation curettage, or endometrial biopsy between July 2012 and July 2013 were included. All data was achieved by examining inpatient medical records retrospectively. Results: The mean age of patients was 52.81±11.47 years. 37.1% of the patients was at menopause. Endometrioid endometrial adenocarcinoma diagnosed in 10 patients (14.2%), papillary serous carcinoma in 1 patient (1.4%) and endometrial stromal sarcoma in 1 patient (1.4%). Non-invasive benign endometrial histological changes were identified in 58 patients (83%). There was no statistically significant difference between the patients with endometrium cancer and without endometrium cancer in terms of MPV, NLR and PLR values (p0.148, p 0.775 and p0.942, respectively). Conclusions: It has been shown in some studies that MPV, NLR and PLR values increase with advanced stage endometrial malignancies and can be used as prognostic factor. However, in order to clearly identify the alternation of these parameters between patients with early-stage endometrial carcinoma and benign endometrial pathology new and comprehensive studies are needed.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Van Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
21
Sayı
3
