The Post-Transplant Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Relation to Graft Function among Renal Transplant Recipients
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Tarih
2020
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info:eu-repo/semantics/openAccess
Özet
Aim: The aim of this study was to evaluate the association of neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio (PLR) with acute rejection after kidneytransplantation.Material and Methods: A total of 36 adult renal transplant recipients (33 males, 3 females)with a median age of 41 (range, 19-64) years were included in this retrospective studyconducted between January 2016 and January 2019. Data on patient demographics andlaboratory findings (neutrophil, lymphocyte, platelet, creatinine, eGFR, serum uric acid andC-reactive protein) were recorded. Acute rejection was defined via renal biopsy in accordancewith Banff criteria.Results: Acute rejection occurred in 16 (44.4%) patients. NLR (median 3.75 vs. 1.99, p=0.001)and PLR (median 125.59 vs. 99.23, p=0.008) values were significantly higher in the acuterejection group than in the control group. Area under the curve was calculated to be 0.822 forNLR and to be 0.759 for PLR. Cut-off values were determined to be >2.5 (75% sensitivity and75% specificity) for NLR and to be >108 (81% sensitivity and 65% specificity) for PLR.Univariate analysis revealed a strong correlation of acute rejection both with NLR >2.5 (OddsRatio (OR)=0.267, 95% Confidence Interval (CI)=0.089-0.803, p=0.019) and PLR >108(OR=0.231, 95% CI=0.066-0.810, p=0.022).Conclusion: In kidney transplant patients, there is a strong relationship between high NLRand PLR values and the development of acute rejection. As simple, easy-to-access, inexpensiveand non-invasive methods, PLR, and particularly NLR, may be potential tests to diagnose posttransplant acute rejection.
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22
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3
