A study on the effects of escitalopram treatment of mean platelet volume in patients with major depression

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dc.contributor.authorCanan, Fatih
dc.contributor.authorAtaoğlu, Ahmet
dc.date.accessioned2020-04-30T22:38:54Z
dc.date.available2020-04-30T22:38:54Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000209020900079en_US
dc.description.abstractIntroduction: The relationship between major depression and increased platelet activity has been previously indicated by several studies. The aim of this study was to examine mean platelet volume (MPV), which is an indicator-of platelet activity, in depressed subjects and investigate whether escitalopram treatment would-affect MPV. Methods: Fifteen patients (11 women and 4 men), meeting the criteria for a current episode of major depressive disorder were participated, as well as 17 physically and mentally healthy comparison subjects (11 women and 6 Men). MPV and platelet count (PLC) at the controls and patients were measured at the entry to the study. After 8 weeks of open-label treatment with the selective serotonin reuptake inhibitor escitalopram (10-20 mg/d), the patients with depression were readmitted and the measurements were repeated. Results: In Comparison with the control-group, the depressed group-exhibited greater platelet activity as detected by increased MPV. After escitalopram treatment, the patients with depression exhibited significant reduction in MPV. Conclusion: In this study, normalization of platelet activation is associated with escitalopram treatment of patients with depression. This finding may provide evidence for-the use of escitalopram in patients with major depression and comorbid ischemic heart disease.en_US
dc.identifier.endpageS241en_US
dc.identifier.issn1017-7833
dc.identifier.startpageS240en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2507
dc.identifier.volume19en_US
dc.identifier.wosWOS:000209020900079en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherKure Iletisim Grubu A Sen_US
dc.relation.ispartofKlinik Psikofarmakoloji Bulteni-Bulletin Of Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEscitalopramen_US
dc.subjectmajor depressionen_US
dc.subjectmean platelet volumeen_US
dc.subjectplatelet activityen_US
dc.titleA study on the effects of escitalopram treatment of mean platelet volume in patients with major depressionen_US
dc.typeArticleen_US

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