A study on the effects of escitalopram treatment of mean platelet volume in patients with major depression
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kure Iletisim Grubu A S
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction: The relationship between major depression and increased platelet activity has been previously indicated by several studies. The aim of this study was to examine mean platelet volume (MPV), which is an indicator-of platelet activity, in depressed subjects and investigate whether escitalopram treatment would-affect MPV. Methods: Fifteen patients (11 women and 4 men), meeting the criteria for a current episode of major depressive disorder were participated, as well as 17 physically and mentally healthy comparison subjects (11 women and 6 Men). MPV and platelet count (PLC) at the controls and patients were measured at the entry to the study. After 8 weeks of open-label treatment with the selective serotonin reuptake inhibitor escitalopram (10-20 mg/d), the patients with depression were readmitted and the measurements were repeated. Results: In Comparison with the control-group, the depressed group-exhibited greater platelet activity as detected by increased MPV. After escitalopram treatment, the patients with depression exhibited significant reduction in MPV. Conclusion: In this study, normalization of platelet activation is associated with escitalopram treatment of patients with depression. This finding may provide evidence for-the use of escitalopram in patients with major depression and comorbid ischemic heart disease.
Açıklama
WOS: 000209020900079
Anahtar Kelimeler
Escitalopram, major depression, mean platelet volume, platelet activity
Kaynak
Klinik Psikofarmakoloji Bulteni-Bulletin Of Clinical Psychopharmacology
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
19
