In Vitro Research on Antimicrobial Activity of Native Anatolian Honey Bee Products against Paenibacillus larvae Strains

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dc.contributor.authorSonmez, Emine
dc.contributor.authorKekecoglu, Meral
dc.contributor.authorBozdeveci, Arif
dc.contributor.authorKaraoglu, Sengul Alapy
dc.date.accessioned2025-10-11T20:48:52Z
dc.date.available2025-10-11T20:48:52Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractWorldwide, one of the most damaging diseases in beekeeping is American Foulbrood (AFB). The causative agent of the disease is Paenibacillus larvae, which can remain in spore form in the environment for decades and does not lose its virulence. In the management of this disease, it is inevitable to find an alternative method to the use of antibiotics and burning the hives. In this study, after determining the Total Phenolic (TPC) and Total Flavonoid Contents (TFC) of seven different Anatolian honey bee products (bee venom, bee bread, pollen, royal jelly, propolis, queen bee larvae, drone brood larvae), in vitro antimicrobial activities of these products against two different P. larvae strains were tested. As a result of Folin-Ciocalteu and AlCl3 colorimetric methods, there were significant differences between the samples, and the highest content values were obtained from the propolis samples. The antimicrobial activity results showed that, P. larvae strains were susceptible to all bee products, except queen bee larvae and drone brood larvae. The most significant inhibition was obtained from Anatolian bee venom with the lowest MIC dose 6.25 mu g mL(-1), Bacterial strains showed susceptibility to Anatolian beebread with an effective dose of 7.81 mu g mL(-1) following bee venom. This study is an important first step in identifying new active compounds for the use of in-hive natural products in the development of new preventive treatments against AFB disease, alternative to conventional antibiotic treatments.en_US
dc.identifier.endpage201en_US
dc.identifier.issn1680-7073
dc.identifier.issn2345-3737
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85216083715en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage189en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22145
dc.identifier.volume27en_US
dc.identifier.wosWOS:001399881800013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTarbiat Modares Univen_US
dc.relation.ispartofJournal of Agricultural Scienceand Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectBee venomen_US
dc.subjectAmerican Foulbrooden_US
dc.subjectAnatolian beebreaden_US
dc.subjectTreatments against AFBen_US
dc.titleIn Vitro Research on Antimicrobial Activity of Native Anatolian Honey Bee Products against Paenibacillus larvae Strainsen_US
dc.typeArticleen_US

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