Role of NO and prostaglandins in acute hypoxic vasoconstriction in sheep pulmonary veins

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dc.contributor.authorUzun, Özge
dc.contributor.authorDemiryürek, Abdullah T.
dc.date.accessioned2020-04-30T23:31:44Z
dc.date.available2020-04-30T23:31:44Z
dc.date.issued2006
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionDemiryurek, Abdullah/0000-0003-4762-4745en_US
dc.descriptionWOS: 000239244100003en_US
dc.descriptionPubMed: 16717478en_US
dc.description.abstractThe aim of this study was to investigate the effect of hypoxia on and the role of nitric oxide (NO) and cyclooxgenase inhibition in hypoxia-induced vasoconstriction in sheep isolated pulmonary veins. We used the potent pulmonary vasoconstrictor U46619, a thromboxane analog, as a precontractile agent. Our results showed that hypoxia caused a vasoconstriction both under resting tone and in U46619 (10(-6) mol/l) precontracted pulmonary veins. In the presence of the nonselective NO synthase inhibitior N omega-nitro-L-arginine methyl ester (L-NAME; 3 x 10(-5) mol/l), the hypoxic pulmonary vasoconstriction (HPV) was significantly increased in veins under resting force. However, there was a decrease in HPV in pulmonaryveins precontracted with U46619 in the presence of L-NAME. Moreover, L-NAME markedly augmented the U46619-induced pulmonary contractions under normoxic conditions. Cyclooxygenase inhibition with indomethacin (10(-5) mol/l) significantly reduced the HPV both under resting tone and in precontracted veins. Indomethacin also significantly decreased the U46619-induced pulmonary contractions prior to the induction of hypoxia. Our findings suggest that NO and prostaglandins can act as a modulators of the hypoxic vasoconstriction in isolated pulmonary veins. Copyright (c) 2006 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000093521en_US
dc.identifier.endpage129en_US
dc.identifier.issn0031-7012
dc.identifier.issue3en_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.1159/000093521
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4441
dc.identifier.volume77en_US
dc.identifier.wosWOS:000239244100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofPharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthypoxiaen_US
dc.subjectpulmonary veinsen_US
dc.subjectN omega-nitro-L-arginine methyl esteren_US
dc.subjectindomethacinen_US
dc.titleRole of NO and prostaglandins in acute hypoxic vasoconstriction in sheep pulmonary veinsen_US
dc.typeArticleen_US

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