EFFECTS OF LITHOSPERMIC ACID SUPPLEMENTATION AGAINST ACUTE EXERCISE-INDUCED OXIDATIVE STRESS IN RATS

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dc.contributor.authorCoknaz, Hakki
dc.contributor.authorKaraoglan, Esen Sezen
dc.contributor.authorOzgen, Ufuk
dc.date.accessioned2025-10-11T20:48:55Z
dc.date.available2025-10-11T20:48:55Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: The aim of the study was to investigate whether lithospermic acid (LSA), a naturally derived polyphenolic compound, supplementation could prevent acute exercise- induced oxidative damage to skeletal muscle tissue in the rats. Material and Method: Rats were randomly selected and divided into three groups (n= 7/group): Group 1Control group (non-exercise, UT), Group 2- Exercise group (exercise, T) and Group 3- Exercise+lithospermic acid group (exercise+lithospermic acid, T/LSA). At the end of the exercise protocol, the samples were removed from the right leg quadriceps muscle. Malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH) and superoxide dismutase (SOD) levels were measured in the muscle samples. Result: Compared to the UT group, malondialdehyde (MDA) and myeloperoxidase (MPO) activity levels in the muscle tissue of the T group significantly increased (p<0.001). MDA and MPO activity levels significantly decreased in the T/LSA group compared to the T group (p<0.05). Glutathione (GSH) and superoxide dismutase (SOD) activity levels significantly decreased in the T group compared to the UT group (p<0.05). GSH and SOD activity levels in muscle tissue significantly increased in the T/LSA group compared to the T group (p<0.05). No significant difference was found in MDA, MPO, GSH, and SOD levels between the UT group and T/LSA group (p>0.05). Conclusion: In conclusion, our study shows that oxidative activity levels in the muscle tissue of the T/LSA group decreased significantly in skeletal muscle-induced acute exercise in rats, so it can be considered that lithospermic acid has a protective effect against oxidative damage.en_US
dc.identifier.endpage212en_US
dc.identifier.issn1305-2381
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85214868387en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22149
dc.identifier.volume20en_US
dc.identifier.wosWOS:001395716600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNobel Ilacen_US
dc.relation.ispartofNobel Medicusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectAntioxidanten_US
dc.subjectacute exerciseen_US
dc.subjectlithospermic aciden_US
dc.subjectoxidative stressen_US
dc.subjectfree radicalen_US
dc.titleEFFECTS OF LITHOSPERMIC ACID SUPPLEMENTATION AGAINST ACUTE EXERCISE-INDUCED OXIDATIVE STRESS IN RATSen_US
dc.typeArticleen_US

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