Seks hormonlarının dişi tavşanlarda mesane fonksiyonları üzerine etkileri: Ürodinami çalışması
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2004
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info:eu-repo/semantics/openAccess
Özet
Farklı seks hormonlarının kullanımı ile mesanede, ürodinamik olarak kapasite ve komplians değişiklikleri olmaktadır. Bu çalışmanın amacı, daha önce erkek tavşanlarda yaptığımız çalışmanın devamı olarak, seks hormonlarının dişi tavşan mesanesi üzerindeki ürodinamik etkilerini araştırmaktır. Çalışmamızda hamile olmayan Yeni Zelanda tipi beyaz dişi tavşanlar kullanıldı. Denekler beş ayrı gruba ayrıldı. G-I: Laparatomi (L) %0,9NaCl. G-II: L Östrojen. G-III: L Bilateral Ooferektomi (BO) Östrojen. G-IV: LBOProgesteron. G-V: L BO Testesteron. Başlangıç kan seks hormon seviye tayini ve ürodinami uygulandı. Gruplarda bütün deneklerin hormon enjeksiyonunu takip eden 5. 10. ve 30. günlerde ürodinamik incelemeleri tekrarlanarak kapasite ve komplians değerleri kaydedildi. Ayrıca takip süresince kan östrojen, progesteron ve testesteron seviyeleri düzenli olarak ölçüldü. Bulgular: Verilen tedaviler ile deneklerde 5. ve 10. günlerde kan hormon düzeylerinde artma saptanmış, bu değerler 30. günün sonunda normal seviyelerine dönmüşlerdir. G-I: mesane kapasitesi ve kompliansta belirgin bir değişiklik saptanmadı. G-II ve III: 5. ve 10. günlerde istatistiksel anlamlı mesane kapasite ve komplians artışı saptandı (p0,005). G–IV: Komplians ve kapasite değişiklik saptanmadı. G-V: 10. günde mesanede kapasite ve komplians düştü, ancak bu düşüş istatistiksel olarak anlamlı değildi (p0,005). Sonuç: Dişi tavşanlarda progesteron ve testosteron uygulaması mesane kapasite ve komplians değerlerinde hafifçe düşmeye, buna karşın östrojen ise artışa neden olmaktadır.
Background.- We previously reported the effects of different sex hormones on bladder urodynamics in male rabbits. The aim of this study was to investigate the effects of different sex hormones on bladder urodynamics in female rabbits. Methods.- Mature female New Zealand white nonpregnant rabbits were studied in five groups. G-I: Sham operation {laparotomy (L)} intramuscular 0.9% NaCl injection. G-II: L Estrogen. G-III: L Bilateral Oopherectomy (BO) Estrogen. G-IV: L BO Progesterone. G-V: L BO Testosterone. Baseline urodynamic findings were recorded and the blood sex hormone levels were measured. All rabbits underwent urodynamic investigations on the 5 th, 10 th and 30 th postinjection days. Blood levels of estrogen, progesterone and testosterone were also measured during the follow-up period. Results.- Blood levels of hormones were found increased on the 5th and 10th days after the injection, but decreased to normal level on the 30th day. There were no significant changes in bladder capacity and compliance in G-I. The bladder capacity and compliance were found to be increased in G-II and G-III on the 5th and 10th days (p<0.05). There were no significant changes in G-IV. There was an insignificant decline (p>0.05) in the bladder capacity and compliance on the 10 th day in G-V. Conclusion.- There was a slight decrease in the bladder capacity and the compliance of the female rabbits after progesterone and testosterone injections. Contrary to this, there was an increase in the bladder capacity and the compliance correlated with the high blood level of estrogen hormone.
Background.- We previously reported the effects of different sex hormones on bladder urodynamics in male rabbits. The aim of this study was to investigate the effects of different sex hormones on bladder urodynamics in female rabbits. Methods.- Mature female New Zealand white nonpregnant rabbits were studied in five groups. G-I: Sham operation {laparotomy (L)} intramuscular 0.9% NaCl injection. G-II: L Estrogen. G-III: L Bilateral Oopherectomy (BO) Estrogen. G-IV: L BO Progesterone. G-V: L BO Testosterone. Baseline urodynamic findings were recorded and the blood sex hormone levels were measured. All rabbits underwent urodynamic investigations on the 5 th, 10 th and 30 th postinjection days. Blood levels of estrogen, progesterone and testosterone were also measured during the follow-up period. Results.- Blood levels of hormones were found increased on the 5th and 10th days after the injection, but decreased to normal level on the 30th day. There were no significant changes in bladder capacity and compliance in G-I. The bladder capacity and compliance were found to be increased in G-II and G-III on the 5th and 10th days (p<0.05). There were no significant changes in G-IV. There was an insignificant decline (p>0.05) in the bladder capacity and compliance on the 10 th day in G-V. Conclusion.- There was a slight decrease in the bladder capacity and the compliance of the female rabbits after progesterone and testosterone injections. Contrary to this, there was an increase in the bladder capacity and the compliance correlated with the high blood level of estrogen hormone.
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