High rate of hepatitis B virus DNA positivity in anti-HBc only-positive patients [?zole anti-HBc pozitif hastalarda saptanan yüksek hepatit B virusu DNA oran?]
| dc.contributor.author | Yıldırım, Mustafa | |
| dc.contributor.author | Yavuz, M. Tevfik | |
| dc.contributor.author | Özdemir, Davut | |
| dc.contributor.author | Behçet, Mustafa | |
| dc.contributor.author | Şencan, İrfan | |
| dc.date.accessioned | 2020-04-30T13:32:33Z | |
| dc.date.available | 2020-04-30T13:32:33Z | |
| dc.date.issued | 2008 | |
| dc.department | DÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
| dc.description | PubMed ID: 18822901 | en_US |
| dc.description.abstract | In hepatitis B virus (HBV) infections, detection of only anti-HBc in the absence of HBsAg and anti-HBs is known as 'anti-HBc only' situation. In this study we investigated the rate of HBV-DNA positivity in anti-HBc only-positive 45 patients (29 male, 16 female; mean age: 39.2 ± 12.3 years) who were followed in the outpatient clinics of a University Hospital in Düzce (located at northern west part of Turkey). HBV markers were investigated by 3rd generation ELISA (ME-IA Axsym-Abbott), and HBV-DNA were searched by real-time PCR [extraction: Minielute (Qiagen, Germany); PCR kits: Florion HBV (Iontek, Turkey); detection: i-cycler IQ5 (BioRad, USA)] methods. As a result, 24.4% (11/45) of the patients were found HBV-DNA positive (> 103 copies/ml). There was no statistically significant difference of HBV-DNA positivity rates between males (9/29; 31%) and females (2/16; 12.5%), (p=0.15). It was concluded that there may be a serious risk of HBV transmission from anti-HBc only-positive patients since the rate of HBV-DNA positivity was found high in our study. Thus HBV-DNA screening should be performed in 'anti-HBc only' patient groups. | en_US |
| dc.identifier.endpage | 536 | en_US |
| dc.identifier.issn | 0374-9096 | |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.scopusquality | Q4 | en_US |
| dc.identifier.startpage | 535 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12684/345 | |
| dc.identifier.volume | 42 | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.indekslendigikaynak | PubMed | en_US |
| dc.language.iso | tr | en_US |
| dc.relation.ispartof | Mikrobiyoloji Bulteni | en_US |
| dc.relation.publicationcategory | Diğer | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | High rate of hepatitis B virus DNA positivity in anti-HBc only-positive patients [?zole anti-HBc pozitif hastalarda saptanan yüksek hepatit B virusu DNA oran?] | en_US |
| dc.type | Letter | en_US |
