Squamous cell carcinoma of the lung with osteoclast- like giant cells: A rare case
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Tarih
2010
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info:eu-repo/semantics/openAccess
Özet
Osteoklast benzeri multinükleer dev hücreler içeren stromal reaksiyonlar karsinomlarda nadir olarak görülür, akciğer karsinomlarında ise daha da nadirdir. Radyolojik olarak sağ akciğerinde volüm kaybına sebep olan 61 yaşındaki erkek hasta kliniğe kabul edildi. Hastaya yapılan bronkoskopide sağ üst lob bronşundan kaynaklanan ve sağ ana bronşu tama yakın tıkayan endobronşiyal lezyon tespit edildi. Lezyondan multipl biyopsiler alındı. Biyopsi sonucu osteoklast benzeri multinükleer dev hücreler içeren non-small cell karsinom olarak raporladık. Hastaya sağ torakotomi ile sleeve üst lobektomi yapıldı. Postoperatif tanıyı osteoklast benzeri multinükleer dev hücreler içeren az diferansiye skuamöz hücreli karsinoma olarak raporladık. Hasta 42. ayında ve sorunsuz olarak takip edilmektedir. Osteoklast benzeri multinükleer dev hücreler içeren karsinomlar meme, tiroid, karaciğer, safra kesesi, mide, pankreas, prostat ve endometriumda çok sayıda raporlanmıştır, ancak akciğer karsinomlarında oldukça az sayıdadır. Osteoklast benzeri multinükleer dev hücreler içeren akciğer karsinomlarının ayırıcı tanısı önemlidir çünkü bu karsinomlar yabancı cisim tipi stromal reaksiyonlar ve dev hücreli karsinomlarla karışabilir.
Stromal reactions including benign osteoclast-like giant cells are rarely seen within carcinomas. They are even extremely rare in lung carcinomas. A 61-year-old male patient who had marked volume loss in the right lung radiologically was admitted. Fiberoptic bronchoscopy was performed, an endobronchial lesion arising from the right upper lobe bronchus and nearly completely obstructing the right main bronchus was detected and multiple biopsies were taken. Histopathological examination of these biopsies confirmed a non-small cell carcinoma with osteoclast-like multinuclear giant cells. A sleeve upper lobectomy was performed through a right thoracotomy. Histopathological examination of the specimen showed “poorly differentiated squamous cell carcinoma and osteoclast-like multinuclear giant cells within”. The patient is well and disease-free 42 months after the operation. There are numerous cases of osteoclast-like giant cells reported within the breast, thyroid, liver, gall bladder, stomach, pancreas, urinary bladder and endometrium but they are very rare within lung carcinomas. A diagnosis of lung carcinoma with osteoclast-like giant cells is very important as it may cause diagnostic confusion with giant cell carcinomas and foreign body type stromal reactions.
Stromal reactions including benign osteoclast-like giant cells are rarely seen within carcinomas. They are even extremely rare in lung carcinomas. A 61-year-old male patient who had marked volume loss in the right lung radiologically was admitted. Fiberoptic bronchoscopy was performed, an endobronchial lesion arising from the right upper lobe bronchus and nearly completely obstructing the right main bronchus was detected and multiple biopsies were taken. Histopathological examination of these biopsies confirmed a non-small cell carcinoma with osteoclast-like multinuclear giant cells. A sleeve upper lobectomy was performed through a right thoracotomy. Histopathological examination of the specimen showed “poorly differentiated squamous cell carcinoma and osteoclast-like multinuclear giant cells within”. The patient is well and disease-free 42 months after the operation. There are numerous cases of osteoclast-like giant cells reported within the breast, thyroid, liver, gall bladder, stomach, pancreas, urinary bladder and endometrium but they are very rare within lung carcinomas. A diagnosis of lung carcinoma with osteoclast-like giant cells is very important as it may cause diagnostic confusion with giant cell carcinomas and foreign body type stromal reactions.
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Cerrahi
Kaynak
Türk Patoloji Dergisi
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Scopus Q Değeri
Cilt
26
Sayı
1
