Could Nucleolin and Nucleophosmin Levels Be Prognostic Indicators in Non-Small Cell Lung Cancer?
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Dosyalar
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
University of Nis, Faculty of Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Lung cancer is the leading cause of mortality from cancer across the world. In this study, the use of serum nucleolin (NCL) and nucleophosmin (NPM1) levels as a marker in the diagnosis, prognosis and treatment response evaluation in lung cancer was investigated. Materials and Method: NCL and NPM1 levels of serum samples taken before chemotherapy and after 3-4 courses of chemotherapy from the control group and the patients diagnosed with lung cancer were studied using ELISA method. Results: Serum NCL and NPM1 levels of the patients were higher than of the controls (p = 0.085 for NCL, p = 0.000 for NPM1). NCL and NPM1 levels by histopathologic type were significantly higher in adenocarcinoma than in squamous cell carcinoma (p < 0.05 for each). In view of the treatment responses to chemotherapeutic agents, there was a statistically insignificant difference between the values before and after chemotherapy (p > 0.05 for each). Conclusion: High serum NCL and NPM1 levels were found to correlate with poor prognosis, poor treatment response and low survival rate. It can be concluded that serum NCL and NPM1 levels in lung cancer can be used as diagnostic and prognostic markers for the disease. © 2022 Sciendo. All rights reserved.
Açıklama
Anahtar Kelimeler
cancer, nucleolin, nucleophosmin, nucleolin, nucleophosmin, adenocarcinoma, adult, Article, cancer chemotherapy, cancer diagnosis, cancer growth, cancer prognosis, cancer size, cancer therapy, clinical article, correlation analysis, enzyme linked immunosorbent assay, histopathology, human, human tissue, lymph node metastasis, middle aged, mortality, non small cell lung cancer, overall survival, squamous cell carcinoma, survival rate, treatment response
Kaynak
Acta Facultatis Medicae Naissensis
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
39
Sayı
4
