Alterations of Serum Copper and Zinc Levels, and Copper/Zinc Ratios Among Patients with Brucellosis

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dc.contributor.authorÜstün, Cemal
dc.contributor.authorTeğin, İbrahim
dc.contributor.authorGeyik, Mehmet Faruk
dc.date.accessioned2020-04-30T22:39:05Z
dc.date.available2020-04-30T22:39:05Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionTegin, Ibrahim/0000-0002-5661-7195; Geyik, Mehmet Faruk/0000-0002-0906-0902en_US
dc.descriptionWOS: 000309698500011en_US
dc.description.abstractObjective: To determine the alterations of serum copper (Cu) and zinc (Zn) levels and Cu/Zn ratio in patients with brucellosis. Material and Methods: A total of 170 individuals were included in the study. Of these, 45 (26.5%) currently had acute or sub-acute brucellosis, 35 (20.6%) were previously diagnosed with acute or sub-acute brucellosis and successfully treated, and 90 (52.9%) were healthy volunteers. After fasting overnight for 10 hours, 5 ml of venous blood was taken from all subjects. Serum Cu and Zn levels were measured using a Unicam 929 Atomic Absorption Spectrophotometer. SPSS 16.0 was used for data analysis. Results: Mean serum Cu levels of 45 patients with acute or sub-acute brucellosis, 35 patients previously diagnosed with acute or sub-acute brucellosis and 90 healthy volunteers were 88.6 +/- 26, 58.7 +/- 13 and 56.7 +/- 16 mu g/dL, respectively. Mean serum Zn levels of 45 patients with acute or sub-acute brucellosis, 35 patients previously diagnosed with and treated successfully for acute or sub-acute brucellosis and 90 healthy volunteers were 38.3 +/- 12, 58.5 +/- 14, and 55.8 +/- 13 mu g/dL, respectively. Serum Cu levels (p<0.001) and Cu/Zn ratios (p<0.001) were statistically significantly higher while serum Zn levels (p<0.001) were lower in patients with acute or sub-acute brucellosis when compared to the individuals who previously diagnosed with acute or sub-acute brucellosis and the healthy volunteers. Conclusion: This study revealed significant alterations of serum Cu and Zn levels, and Cu/Zn ratios in patients with acute or sub-acute brucellosis. Serum Cu, Zn, and Cu/Zn ratios may be available biomarkers in the course of acute or sub-acute brucellosis.en_US
dc.identifier.doi10.5336/medsci.2011-25720en_US
dc.identifier.endpage983en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage979en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2011-25720
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2594
dc.identifier.volume32en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrucellosisen_US
dc.subjectcopperen_US
dc.subjectzincen_US
dc.subjecttrace elementsen_US
dc.subjectserumen_US
dc.subjectbiological markersen_US
dc.titleAlterations of Serum Copper and Zinc Levels, and Copper/Zinc Ratios Among Patients with Brucellosisen_US
dc.typeArticleen_US

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