Synthesis and Biological Evaluation of Imidazole-2-thione Fused Furazan as a New Biheterocyclic Scaffold

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dc.contributor.authorKurt, Gülşah
dc.contributor.authorSevgı, Fatıh
dc.date.accessioned2023-04-10T20:28:03Z
dc.date.available2023-04-10T20:28:03Z
dc.date.issued2022
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractA new imidazole-2-thione fused furazan biheterocyclic group was synthesized and its biological activity was investigated. Nitrogen rich heterocycles, imidazole-2-thione and 1,2,5-oxadiazole (furazan) have been conveni ently fused. To accomplish this, we have improved a new strategy that silica gel supported solvent free micro wave dehydration of vicinal dioximes. The target furazan "N,N’-diphenyl-4H-imidazo[4,5-c]furazan-5(6H) –thio ne" [II] (DFTFrz) was obtained from (4E,5Z)-4,5-bis(hydroxyimino)-N,N’-diphenylimidazolidine-2-thione [I] (DFTD) with acceptable yield and characterized by LC-MS/MS, FT-IR and NMR spectroscopy. The biological evaluation of the obtained thiourea furazan and its precursor dioxime were investigated by antibacterial effect studies using broth microdilution and disc diffusion methods. It was observed that thioure furazan was more effective on the tested pathogenic bacteria than its precursor dioxime. The compounds did not show any effect on gram negative bacteria, while they exhibited a moderate effect on gram positive bacteria, especially Staphylococcus spp.en_US
dc.identifier.doi10.29130/dubited.880667
dc.identifier.endpage26en_US
dc.identifier.issn2148-2446
dc.identifier.issue1en_US
dc.identifier.startpage14en_US
dc.identifier.trdizinid1123352en_US
dc.identifier.urihttp://doi.org/10.29130/dubited.880667
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1123352
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11872
dc.identifier.volume10en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Üniversitesi Bilim ve Teknoloji Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThioureaen_US
dc.subjectFurazanen_US
dc.subjectImidazole-2-thioneen_US
dc.subjectBiheterocyclicen_US
dc.subjectAntibacterial Tiyoüreen_US
dc.subjectFurazanen_US
dc.subjectImidazol-2-tiyonen_US
dc.subjectİkili heterohalkaen_US
dc.subjectAntibakteriyelen_US
dc.titleSynthesis and Biological Evaluation of Imidazole-2-thione Fused Furazan as a New Biheterocyclic Scaffolden_US
dc.typeArticleen_US

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