Clinicopathological Features of Gastrointestinal Stromal Tumors and Review of the Literature: A Single Institution Experience

Basit Öğe Kaydı
dc.contributor.authorCoşkun, Sinem Kantarcıoğlu
dc.date.accessioned2023-07-26T11:49:53Z
dc.date.available2023-07-26T11:49:53Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Pataloji Ana Bilim Dalıen_US
dc.description.abstractObjective: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasias of the gastrointestinal system (GIS). The malignancy potential of GISTs may vary ranging from indolent tumors to progressive malignant tumors. This study aims to define clinicopathological and immunohistochemical features of GISTs diagnosed in our institute with a review of the literature. Methods: A total of 28 GIST cases were included in the study. The Hematoxylin&Eosin stained slides of surgical resection materials and cell blocks and immunohistochemistry performed slides were reviewed by a pathologist. The immunohistochemical expression with CD117, DOG-1, CD34, SMA, and S100 was scored between 0 and 3 points according to staining intensity. Descriptive statistics were used in the study. The demographic data, prognostic histopathological, and immunohistochemical findings are evaluated with the literature indications. Results: Eleven of the cases were male and seventeen were female. The age range was 18-88. The most common site of GISTs was the stomach, followed by the small intestine, colorectal region, and, esophagus. Twenty of the tumors were resected surgically, four were endoscopic biopsy material and four were fine-needle aspiration biopsies. The tumor size in measurable materials ranged from 0,2 to 22 cm. The mitotic count in 50 HPF ranges from 0 to 10. Seven of the GISTs were high grade and the remaining 21 were low grade. The majority of the cases were composed of spindle cells, 3 were epithelioid and 3 were the mixed type with spindle and epitheloid cells. Conclusions: A variety of criteria has been proposed to estimate the malignancy potential of GISTs and predict prognosis but definite prognostic criteria remain uncertain. Further studies with larger series of GISTs consisting of different types of biopsy materials may help define criteria to predict prognosis precisely.en_US
dc.identifier.doi10.18521/ktd.1094503
dc.identifier.endpage379en_US
dc.identifier.issn1309-3878
dc.identifier.issue2en_US
dc.identifier.startpage373en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.1094503
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12152
dc.identifier.volume14en_US
dc.identifier.wosWOS:000821703000012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorCoşkun, Sinem Kantarcıoğlu
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofKonuralp Tıp Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectGastrointestinal Stromal Tumors; Cd117; Dog-1; Cd34; Prognosisen_US
dc.subjectSoft-Tissue Sarcomas; Definition; Malignancy; Pathology; Criteriaen_US
dc.titleClinicopathological Features of Gastrointestinal Stromal Tumors and Review of the Literature: A Single Institution Experienceen_US
dc.typeReview Articleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
12152.pdf
Boyut:
922.21 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Konuralp Tip Dergisi Koleksiyonu