Clinical findings and BTD gene molecular analysis results of patients presenting with suspicion of biotinidase deficiency

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dc.contributor.authorEröz, Recep
dc.contributor.authorTuran, Betül
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorYüce, Hüseyin
dc.contributor.authorKocabay, Kenan
dc.contributor.authorÖzmerdivenli, Recep
dc.date.accessioned2020-04-30T13:32:12Z
dc.date.available2020-04-30T13:32:12Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: Biotinidase deficiency is an autosomal recessive disease, also known as late-onset biotin-sensitive multiple carboxylase deficiency caused by pathogenic mutations in the biotinidase (BTD) gene responsible for the production of biotinidase. In this study, we aimed to present the clinical findings and BTD gene molecular analysis results in the light of the literature. Material and Methods: Nine patients who were positive in heel blood screening and cases compatible with neurological, sensory, metabolic, respiration and skin findings of biotinidase deficiency were included in the study. For the isolation of genomic DNA from the participants included in the study, 2 cc of peripheral blood was taken into Ethylene Diamine Tetra Acetic Acid (EDTA) tubes and their genomic DNA was isolated and sequence analysis of the BTD gene was performed. Results: According to the all exon sequence analysis results of the BTD gene, homozygous c.1368A>C/p.Gln456His mutation was detected in 1 patient; heterozygous c.1368A>C/p.Gln456His mutation was detected in 1 patient; combined heterozygous c.1330G>C/p.Asp444His and c.511G>A/p.Ala171Thr mutations were detected in 1 patient, combined heterozygous c.1336G>C/p.Asp446His and c.511G>A/p.Ala171Thr were detected in 1 patient, and c.557G>A/p.Cys186Tyr mutation was detected in 1 patient. No mutation was detected in 4 patients. Conclusion: Early diagnosis and treatment are very important for eliminating the problems experienced by patients with BTD disorder and for preventing complications that may occur in case of delay. It is important that informing the patient and family members about the prenatal diagnosis or preimplantation genetic diagnosis method for autosomal recessive inherited disease by giving genetic counseling. © 2018, Duzce University Medical School. All rights reserved.en_US
dc.identifier.endpage80en_US
dc.identifier.issn1307671X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/159
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiotinidase deficiency; BTD gene; Late-onset biotine sensitive multiple carboxylase deficiencyen_US
dc.titleClinical findings and BTD gene molecular analysis results of patients presenting with suspicion of biotinidase deficiencyen_US
dc.title.alternativeBiyotinidaz eksikliği şüphesiyle başvuran hastaların klinik bulguları ve BTD geni moleküler analizi sonuçlarıen_US
dc.typeArticleen_US

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