The Effect of Rhododendron Honey on Mice Liver Tissue

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dc.contributor.authorKükner, Aysel
dc.contributor.authorİlter, Gizem
dc.contributor.authorSöyler, Gizem
dc.contributor.authorRasgele, Pınar Göç
dc.contributor.authorKekeçoğlu, Meral
dc.contributor.authorKambur, Merve
dc.date.accessioned2020-04-30T23:33:09Z
dc.date.available2020-04-30T23:33:09Z
dc.date.issued2016
dc.departmentDÜ, Ziraat Fakültesi, Biyosistem Mühendisliği Bölümüen_US
dc.descriptionWOS: 000387656400004en_US
dc.description.abstractRhododendron honey, made by bees from rhododendron pollen, contains a toxic substance called grayanotoxin. Depending on the dose, the poisonous honey can result in serious effects such as cardiac arrhythmia, fibrillation, and myocardial infarction. The purpose of this study is to investigate the effects of the poisonous RH of the Black Sea Region on the liver. Male mice were divided into five groups of twelve mice each, two being the control groups (distilled water) and the others being the rhododendron honey (RH) groups (25, 50, and 75 mg/kg) and 0.01 mg/kg grayanotoxin (GTx) groups. Liver tissues were collected 24 and 48 h later. The sections were stained with hematoxylin, eosin and PAS, then the histopathological score was performed. Significant statistical differences were observed between the RH and control groups in terms of congestion, steatosis, sinusoid dilatation, and inflammation. The control group demonstrated a normal liver structure in the light microscopy, while the GTx-applied 24 h group exhibited expansions in the sinusoids and congestion. Higher levels of congestion, steatosis, and inflammatory cells were seen in the GTx-applied 48 h group. In the same group, giant cells consisting of many nuclei were observed in the sinusoids. The results of the 25 mg RH-applied groups were similar in 24 and 48 h, histopathological score levels were increased slightly, congestion and steatosis were prominent in the 48 h group. Dense steatosis was seen in the hepatocytes around the vena centralis in 50 mg/kg RH-applied 48 h group. Congestion, steatosis and an increase in inflammatory cells were observed in the hepatocytes in the 75 mg/kg RH-applied 24- and 48 h groups. PAS (+) stained hepatocytes were decreased in the RH-and GTx-applied groups. The toxic effects of the rhododendron honey were observed in the mice liver tissue with respect to dose and time.en_US
dc.identifier.endpage847en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue3en_US
dc.identifier.startpage842en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4905
dc.identifier.volume34en_US
dc.identifier.wosWOS:000387656400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal Of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRhododendron honeyen_US
dc.subjectMiceen_US
dc.subjectLiveren_US
dc.titleThe Effect of Rhododendron Honey on Mice Liver Tissueen_US
dc.typeArticleen_US

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