Deneysel Omurilik Yaralanmasında İsotretinoinin Nörorejenerasyon Üzerine Klinik ve Histopatolojik Etkileri
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Düzce Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Omurilik yaralanması önemli bir sorundur ve henüz tam olarak etkili bir tedavi geliştirilememiştir. İsotretinoin, anti-inflamatuar etkisiyle bilinen bir retinoiddir. Bu çalışmanın amacı, yaralanma sonrası sinir dokusu üzerinde isotretinoinin olumlu bir etkisinin olup olmadığını değerlendirmektir.Gereç ve Yöntemler: Toplam 36 sıçan kontrol, sham ve travma ile 14 günlük 7,5 mg/kg/gün, 28 günlük 7,5 mg/kg/gün, 14 günlük 15 mg/kg/gün ve 28 günlük 15 mg/kg/gün isotretinoin grupları olmak üzere 6 gruba ayrıldı. Sıçanlara laminektomi yapıldı ve omurilik yaralanması klip kompresyon tekniği kullanılarak oluşturuldu. Nörolojik muayene 1, 7, 14 ve 28. günlerde yapıldı. Tedavi süresinden sonra tüm sıçanlar öldürüldü ve histopatolojik değerlendirme için omurilik örnekleri toplandı.Bulgular: 7,5 mg/kg/gün (p=0,048) ve 15 mg/kg/gün (p
Aim: Spinal cord injury is an important problem, and a fully effective treatment for it has not yet been developed. Isotretinoin is a retinoid known for its anti-inflammatory effect. The present study aimed to evaluate whether isotretinoin has a positive impact on neural tissue in post-injury damage.Material and Methods: A total of 36 rats were randomly divided into 6 groups as control, sham, and injury with 14-day 7.5 mg/kg/day, 28-day 7.5 mg/kg/day, 14-day 15 mg/kg/day, and 28-day 15 mg/kg/day isotretinoin groups. Laminectomy was performed and spinal cord injury was produced by using the clip compression technique. Neurological examination was performed on days 1, 7, 14, and 28. After the treatment period, all rats were sacrificed, and their spinal cord samples were collected for histopathological assessment.Results: Groups receiving 7.5 mg/kg/day (p=0.048) and 15 mg/kg/day (p
Aim: Spinal cord injury is an important problem, and a fully effective treatment for it has not yet been developed. Isotretinoin is a retinoid known for its anti-inflammatory effect. The present study aimed to evaluate whether isotretinoin has a positive impact on neural tissue in post-injury damage.Material and Methods: A total of 36 rats were randomly divided into 6 groups as control, sham, and injury with 14-day 7.5 mg/kg/day, 28-day 7.5 mg/kg/day, 14-day 15 mg/kg/day, and 28-day 15 mg/kg/day isotretinoin groups. Laminectomy was performed and spinal cord injury was produced by using the clip compression technique. Neurological examination was performed on days 1, 7, 14, and 28. After the treatment period, all rats were sacrificed, and their spinal cord samples were collected for histopathological assessment.Results: Groups receiving 7.5 mg/kg/day (p=0.048) and 15 mg/kg/day (p
Açıklama
Anahtar Kelimeler
İsotretinoin, Nörorejenerasyon, Omurilik yaralanması, Isotretinoin, Neuroregeneration, Spinal cord injury
Kaynak
Düzce Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
26
Sayı
3
