Evaluation of in vivo DNA damaging and oxidative stress effects of sertraline

Basit Öğe Kaydı
dc.contributor.authorAktas, Ayca
dc.contributor.authorBattal, Dilek
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorYalin, Serap
dc.contributor.authorKadioglu, Ela
dc.contributor.authorEker, Ebru Derici
dc.contributor.authorSaygi, Sahan
dc.contributor.authorAktaş, Ayça
dc.contributor.authorBattal, Dilek
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorYalın, Serap
dc.contributor.authorKadıoğlu, Ela
dc.contributor.authorEker, Ebru Derici
dc.contributor.authorSaygı, Şahan
dc.date.accessioned2020-05-01T12:16:40Z
dc.date.available2020-05-01T12:16:40Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description49th Congress of the European-Societies-of-Toxicology (EUROTOX) -- SEP 01-04, 2013 -- Interlaken, SWITZERLANDen_US
dc.descriptionWOS: 000323865800391en_US
dc.description.abstractSertraline, SSRI group of medicine, is the most frequently prescribed drug and well-known fact that central nervous system medication. In this study, the potential influence of the therapies with the different doses of sertraline on DNA damaging, lipid peroxidation levels and antioxidant enzyme activities were investigated. For this purpose Male Wistar Albino rats were divided into four group: control (n = 6), low (10 mg/kg/day), moderate (40 mg/kg/day), and high dose (80 mg/kg/day). Each treatment group had 6 animals and sertraline were administered by gavage throughout 28 days of the study. The alkaline comet assay and the cytokinesis-block micronucleus (CBMN) assay were used to evaluate DNA damaging potential of sertraline in the peripheral blood lymphocytes (PBLs). There is no statistically significant difference between sertraline treated groups and the negative control group with respect to comet assay results (p > .05). According to the data obtained from the CBMN test, an increase in the micronucleus (MN) frequency was detected only at high dose sertraline treatment. Serum paroxanase (PON), catalase (CAT), and superoxyde dismutase (SOD) activities were determined as well as malondialdehyde (MDA) lipid peroxidation for evaluation of oxidative stress effects of sertraline treatment. Serum SOD activities showed increase, CAT and PON activities decreased in all groups. Lipid peroxidation levels (MDA) increased in all sertraline treated rats (p < 0.05). Based on the data, it can be concluded that high dose sertraline administration enhances oxidative stress. Therefore, dose adjustment in depression patients seems significant as it may help prevention of further prognosis of the diseases.en_US
dc.description.sponsorshipEuropean Soc Toxicol (EUROTOX), ECETOC, Roche, Syngenta, AstraZeneca, Sanofi, Basilea Pharmaceutica, ACEA Biosciences Inc, European Crop Protect, Bioservice Sci Labs GmbH, Oekotoxzentrum Ctr Ecotox, Swiss Confederat, Fed Dept Home Affairs, Fed Off Publ Hlth (FOPH), BASF, SCAHT, Johnson & Johnson, Janssen Pharmaceut Co, Natl Ctr Replacement, Refinement & Reduct Anim Res, ILSI, SERVIER, RCC, Nestle, Suva Pro, Interpharma, Covance, Novartis, Merck, BioRelianceen_US
dc.identifier.doi10.1016/j.toxlet.2013.05.236en_US
dc.identifier.endpageS128en_US
dc.identifier.issn0378-4274
dc.identifier.startpageS128en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxlet.2013.05.236
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6407
dc.identifier.volume221en_US
dc.identifier.wosWOS:000323865800391en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofToxicology Lettersen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEvaluation of in vivo DNA damaging and oxidative stress effects of sertralineen_US
dc.typeConference Objecten_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
6407.pdf
Boyut:
79.87 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Bildiri Koleksiyonu