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Öğe Evaluation of in vivo DNA damaging and oxidative stress effects of sertraline(Elsevier Ireland Ltd, 2013) Aktas, Ayca; Battal, Dilek; Sungur, Mehmet Ali; Yalin, Serap; Kadioglu, Ela; Eker, Ebru Derici; Saygi, Sahan; Aktaş, Ayça; Battal, Dilek; Sungur, Mehmet Ali; Yalın, Serap; Kadıoğlu, Ela; Eker, Ebru Derici; Saygı, ŞahanSertraline, SSRI group of medicine, is the most frequently prescribed drug and well-known fact that central nervous system medication. In this study, the potential influence of the therapies with the different doses of sertraline on DNA damaging, lipid peroxidation levels and antioxidant enzyme activities were investigated. For this purpose Male Wistar Albino rats were divided into four group: control (n = 6), low (10 mg/kg/day), moderate (40 mg/kg/day), and high dose (80 mg/kg/day). Each treatment group had 6 animals and sertraline were administered by gavage throughout 28 days of the study. The alkaline comet assay and the cytokinesis-block micronucleus (CBMN) assay were used to evaluate DNA damaging potential of sertraline in the peripheral blood lymphocytes (PBLs). There is no statistically significant difference between sertraline treated groups and the negative control group with respect to comet assay results (p > .05). According to the data obtained from the CBMN test, an increase in the micronucleus (MN) frequency was detected only at high dose sertraline treatment. Serum paroxanase (PON), catalase (CAT), and superoxyde dismutase (SOD) activities were determined as well as malondialdehyde (MDA) lipid peroxidation for evaluation of oxidative stress effects of sertraline treatment. Serum SOD activities showed increase, CAT and PON activities decreased in all groups. Lipid peroxidation levels (MDA) increased in all sertraline treated rats (p < 0.05). Based on the data, it can be concluded that high dose sertraline administration enhances oxidative stress. Therefore, dose adjustment in depression patients seems significant as it may help prevention of further prognosis of the diseases.Öğe Examination of Physical Activity Levels of Bartin University Students(Wiley, 2018) Yıldız, Yasemin Şahin; Kılıç, Ümit; Beyazçiçek, Ersin; Beyazçiçek, Özge; Demir, Şerif…Öğe Etiology of portal venous thrombosis and budd-chiari syndrome in adults(Wiley-Blackwell, 2015) Tombak, Anıl; İşgüzar, G.; Uçbilek, E.; Yaras, S.; Akdeniz, A.; Uçar, M.A.; Sungur, M.A.…Öğe Elevated Ionic Strength Diminishes Force/Cross-Bridge and the Number of Force-Generating Cross-Bridges(Cell Press, 2015) Wang, Li; Bahadır, Anzel; Kawai, Masataka…Öğe Effect of Epigallocatechin gallate on Penicillin-induced Epileptiform Activity in Rats(Wiley-Blackwell, 2016) Ankaralı, Seyit; Özcan, Recep; Beyazçiçek, Ersin; Ankaralı, Handan…Öğe Effect of Acute and Chronic Ellagic Acid Administration on Penicillin-induced Epileptiform Activity in Rats(Wiley, 2017) Beyazçiçek, Ersin; Ankaralı, Seyit; Beyazçiçek, Özge; Ankaralı, Handan; Çetinkaya, Ayhan…Öğe Effect of (R)-(-) and (S)-(+) Carvone on the Penicillin-induced Epileptiform Activity in Rats(Wiley-Blackwell, 2016) Beyazçiçek, Özge; Taka, Sümeyye; Demir, Şerif; Beyazçiçek, Ersin; Taşcı, Şeymanur Yılmaz; Bahadır, Anzel; Ankaralı, Handan…Öğe Determination of the Relationship Between Sperm Morphology and DNA Damage in Different Patient Groups(Wiley, 2017) Caner, Burak Cihad; Yay, Arzu; Cantürk, Fazile; Bahadır, Anzel; Sezer, Gülay…Öğe Determination of Plasma Cholecystokinin Levels in Patient With Migraine Without Aura(Wiley, 2017) Alemdar, Hacer; Demir, Şerif; Beyazçiçek, Ersin; Bulduk, Serap…Öğe The Role of Cholecystokinin in the Gastroprotective Effect of Apelin Against to Ischemia/Reperfusion-Induced Injury(Wiley, 2018) Birsen, İlknur; Uysal, V. Nimet İzgüt; Soylu, Hakan; Üstünel, İsmail…Öğe The relevance of associated symptoms of migraine according to migraine subtypes: A Clinical study(Springeropen, 2018) Özge, Aynur; Yalın, Osman Özgür; Uludüz, Derya; Mercan, Özlem; Sungur, Mehmet Ali; Siva, Aksel…Öğe The investigation of lipoprotein associated phospholipase A2 (Lp-PLA2) V279F single point mutation in coronary artery disease(Wiley-Blackwell, 2013) Yaroğlu, Hatice Yıldırım; Akciğer, N.; Sungur, M.A.; Yılmaz, D.C.; Gümüş, Lülüfer Tamer…Öğe The investigation antiproliferative and apoptotic effects of capsaicin and alpha lipoic acid on colon adenocarcinoma cells(Lippincott Williams & Wilkins, 2015) Alpay, Merve; Kısmalı, Görkem; Sel, Tevhide; Karagül, Hilal…Öğe The Evidences of Electrophysiological Symptoms of Acute Toxoplasmosis in Rats(Wiley, 2017) Ayaz, E.; Orallar, H.; Türkoğlu, S.A.; Çetinkaya, A.; Demir, S.…Öğe The effects of usnic acid on the penicillin induced epileptiform activity on rats(Wiley-Blackwell, 2016) Taşçı, Şeymanur Yılmaz; Demir, Şerif; Beyazçiçek, Özge; Beyazçiçek, Ersin; Cangür, Şengül…Öğe The effects of N-acetylcysteine on microsomal and serum paraoxonase 1 activities at high fat diet induced obese rats(Wiley-Blackwell, 2016) Duman, D.; Yücesan, Fulya Balaban; Yaman, Serap Özer; Kahraman, C.; Alver, Ahmet; Canpolat, S.; Örem, Asım…Öğe The Effects of Nigella Sativa Extract and Chronic Exercise Application on Penicillin-induced Epilepsy Model in Mongolian Gerbils(Wiley-Blackwell, 2016) Çetinkaya, Ayhan; Demir, Şerif; Orallar, Hayriye; Kayacan, Yıldırım; Çakır, Serkan; Yıldırım, Arzu; Beyazçiçek, Ersin…Öğe THE EFFECT OF THYMOQUINONE ON PENICILLIN-INDUCED EPILEPTIFORM ACTIVITY IN RATS(Wiley-Blackwell, 2014) Beyazçiçek, Ersin; Ankaralı, Seyit; Beyazçiçek, Özge; Ankaralı, Handan; Demir, Şerif; Özmerdivenli, Recep…Öğe THE EFFECT OF RAPAMYCIN (SIROLIMUS) ON PENICILLIN-INDUCED EPILEPTIFORM ACTIVITY IN RATS(Wiley-Blackwell, 2014) Ankaralı, Seyit; Beyazçiçek, Ersin; Demir, Şerif; Taka, S.; Ankaralı, Handan…Öğe The Effect of Galanin and Exercise on Depression in Rats(Wiley, 2017) Beyazçiçek, Ersin; Mermerci, Asuman; Özmerdivenli, Recep; Beyazçiçek, Özge; Orallar, Hayriye; Sungur, Mehmet Ali…
