Application of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tablets

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dc.contributor.authorBüker, Eda
dc.contributor.authorDinç, Erdal
dc.contributor.authorYaşar, Nagihan
dc.date.accessioned2023-04-10T20:29:31Z
dc.date.available2023-04-10T20:29:31Z
dc.date.issued2022
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractTwo chemometric calibration methods, principal component regression (PCR) and partial least squares regression (PLS) were proposed for the simultaneous spectrophotometric determination of praziquantel (PRA) and ivermectin (IVE) in a marketed veterinary formulation without using preliminary separation step. UV spectra of calibration set and samples including PRA and IVE were recorded in the spectral region of 225-315 nm. PCR and PLS algorithms were applied to absorbance data matrix and concentration set including PRA and IVE in the linear concentration range of 20.0-160.0 ?g/mL for PRA and 2.0-44.0 ?g/mL for IVE. The capability of the PCR and PLS methods were validated by analyzing validation samples. Assay results showed that both PCR and PLS approaches provided an opportunity for quantifying PRA and IVE in veterinary tablet formulation.en_US
dc.identifier.doi10.29130/dubited.1051389
dc.identifier.endpage397en_US
dc.identifier.issn2148-2446
dc.identifier.issue1en_US
dc.identifier.startpage385en_US
dc.identifier.trdizinid1124243en_US
dc.identifier.urihttp://doi.org/10.29130/dubited.1051389
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1124243
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11896
dc.identifier.volume10en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Üniversitesi Bilim ve Teknoloji Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPCR and PLS calibrationsen_US
dc.subjectSimultaneous quantificationen_US
dc.subjectPraziquantelen_US
dc.subjectIvermectinen_US
dc.subjectVeterinary tablet preparation PCR ve PLS kalibrasyonen_US
dc.subjectEşzamanlı miktarsal ölçümen_US
dc.subjectPrazikuantelen_US
dc.subjectIvermectinen_US
dc.subjectVeteriner tabletlerien_US
dc.titleApplication of PCR and PLS Tools for the Simultaneous Quantification of Praziquantel and Ivermectin Binary Mixtures in Veterinary Tabletsen_US
dc.typeArticleen_US

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