Comparison Effects of Serum Antioxidants Levels and Intensity of Inflammatory Cells in Experimental Periodontitis Treated with Low-Dose Doxycycline and Coriandrum Sativum L

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dc.contributor.authorAkpolat, Meryem
dc.contributor.authorAvcı, Bahattin
dc.contributor.authorGülle, Kanat
dc.contributor.authorKurtiş, Mazlum Bülent
dc.contributor.authorDede, Figen Öngöz
dc.contributor.authorBallı, Umut
dc.contributor.authorDoğan, Şeyma Bozkurt
dc.date.accessioned2023-04-10T20:31:07Z
dc.date.available2023-04-10T20:31:07Z
dc.date.issued2022
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: The aim of this study was to evaluate the effects of systemically-administered Coriandrum sativum L (CSL) and low dose doxycycline (LDD) on serum levels of antioxidant enzymes and intensity of inflammatory cells in rats with experimental periodontitis. Material and Methods: Forty adult male Wistar Albino rats were divided randomly into 5 groups as follows: group 1: periodontally healthy (control); group 2: periodontitis; group 3: periodontitis+CSL (32mg/kg); group 4: periodontitis+CSL (200mg/kg); group 5: periodontitis+LDD (6 mg/kg). Serum gingival superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) levels were evaluated by ELISA. The intensity of inflammatory cells were evaluated by histopathologically. Results: SOD levels were statistically lowest in group 1 and statistically were highest in group 2 than those of other groups. There was a statistical difference in SOD levels in paired comparisons of groups 1 and 2 with other groups. Its level did not have statistically significant among groups 3, 4 and 5. CAT levels were statistically lowest in group 2 than those of other groups, and no differences were reported among groups 1, 3, 4, and 5. GSH-Px levels did not have statistically significant among groups. Inflammatory cell infiltration was found to be statistically higher in groups 2 and 4 compared to group 1, and no statistical significance was reported among groups 1, 3, and 5. Conclusion: CSL and LDD application groups did not show differences in terms of serum SOD, serum CAT, and intensity of inflammatory cells. Therefore, we suggest that the different dosages of CSL should be examined in the treatment of periodontitis.en_US
dc.identifier.doi10.33631/sabd.1054420
dc.identifier.endpage452en_US
dc.identifier.issn2792-0542
dc.identifier.issue3en_US
dc.identifier.startpage445en_US
dc.identifier.trdizinid1124750en_US
dc.identifier.urihttp://doi.org/10.33631/sabd.1054420
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1124750
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12075
dc.identifier.volume12en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofSağlık Bilimlerinde Değer (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeriodontitisen_US
dc.subjectCoriander Sativum Len_US
dc.subjectLow Dose doxcyclineen_US
dc.subjectserumen_US
dc.subjectantioxidanten_US
dc.titleComparison Effects of Serum Antioxidants Levels and Intensity of Inflammatory Cells in Experimental Periodontitis Treated with Low-Dose Doxycycline and Coriandrum Sativum Len_US
dc.typeArticleen_US

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