Overexpression of PD-L1 in Papillary Carcinoma and Its Association with Clinicopathological Variables

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dc.contributor.authorTuran, Gulay
dc.contributor.authorKocaöz, Servet
dc.date.accessioned2023-04-10T20:19:40Z
dc.date.available2023-04-10T20:19:40Z
dc.date.issued2021
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: Standard treatment may not be sufficient in patients with metastatic papillary thyroid cancer (PTC), and it may be beneficial to add PD-1 agents to the treatment. Therefore, this study was conducted to compare and evaluate the expression of PD-L1 in patients with nodular goiter (NG) and Hashimoto's thyroiditis (HT) within the scope of PTC carcinoma. Material and Methods: Thirty-five patients from each group who underwent thyroidectomy for NG, HT, and PTC, between January 2011 and December 2017 were identified. Immunohistochemically, an anti-PD-L1 stain was applied by taking new sections from the tissue samples of 105 patients. The histological type, tumour diameter, capsule invasion (CI), and lymphovascular invasion (LVI) were evaluated. Results: Nine (25.7%) of the patients with PTC were defined as classic, 10 (28.6%) as follicular, 6 (17.1%) as oncocytic, 5 (14.3%) as encapsulated, 2 (5.7%) as solid, 1 (2.9%) tall cell, and 2 (5.7%) as Warthin-like. The expression of PD-L1 in the patients with PTC was significantly higher than in the patients with NG and HT (p<0.001). There was a significant relationship between the increased PD-L1 expression and staining intensity and presence of thyroid LVI in the patients with PTC (p=0.047). In addition, the PD-L1 expression and LVI were observed to be more severe in patients with follicular, tall cell, and oncocytic subtype PTC (p=0.011, p=0.026, respectively). Conclusion:ItwasobservedthatthePD-L1expressionincreasedinpatientswithPTC. PD-L1 expression and LVI were more severe in patients with follicular, tall cell, and oncocytic subtype of PTC.en_US
dc.identifier.doi10.18678/dtfd.970511
dc.identifier.endpage257en_US
dc.identifier.issn1307-671X
dc.identifier.issue3en_US
dc.identifier.startpage252en_US
dc.identifier.trdizinid495751en_US
dc.identifier.urihttp://doi.org/10.18678/dtfd.970511
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/495751
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11463
dc.identifier.volume23en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNodular Goiteren_US
dc.subjectPapillary thyroid carcinomaen_US
dc.subjectHashimoto thyroiditisen_US
dc.subjectPD-L1en_US
dc.titleOverexpression of PD-L1 in Papillary Carcinoma and Its Association with Clinicopathological Variablesen_US
dc.typeArticleen_US

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