MBL2 Gene Polymorphism and Risk of Vitiligo in Turkish Patients

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dc.contributor.authorKarkucak, Mutlu
dc.contributor.authorSolak, Berna
dc.contributor.authorTuran, Hakan
dc.contributor.authorUslu, Esma
dc.contributor.authorYakut, Tahsin
dc.contributor.authorAliağaoğlu, Cihangir
dc.contributor.authorErdem, Teoman
dc.date.accessioned2020-04-30T23:19:06Z
dc.date.available2020-04-30T23:19:06Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000362717900001en_US
dc.description.abstractMannose-Binding Lectin (MBL) plays an important role in innate immunity. MBL2 gene polymorphisms affect MBL serum levels. Therefore, this increases the risk of infection and may result in predisposition to autoimmune diseases. The aim of this study was to investigate whether there is an association between the MBL2 gene codon 54 (allele B: rs1800450, c. 161G>A; p. 54Gly>Asp) polymorphism and vitiligo in Turkish patients. One hundred and one patients who were diagnosed with vitiligo and 101 control subjects were included in the study. The DNA was analyzed using the Kbioscience Competitive Allele Specific PCR (KASP) technique. MBL2 gene codon 54 polymorphism frequencies were compared between the two groups. In statistical analysis, the level of significance was set at p<0.05. No significant differences in frequencies of the A allele were observed between the patient and control groups. It was observed at similar frequencies in both groups (p=0.890). The results suggest that the MBL2 gene Codon 54 polymorphism is not associated with an increased risk for the development of vitiligo in Turkish patients.en_US
dc.description.sponsorshipSakarya UniversitySakarya University [2014-08-06-009]en_US
dc.description.sponsorshipThe researchers thank the Sakarya University for funding this research (grant 2014-08-06-009).en_US
dc.identifier.endpage96en_US
dc.identifier.issn0972-3757
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3650
dc.identifier.volume15en_US
dc.identifier.wosWOS:000362717900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKamla-Raj Enterprisesen_US
dc.relation.ispartofInternational Journal Of Human Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMannose-Binding Lectinen_US
dc.subjectPolymorphismen_US
dc.subjectVitiligoen_US
dc.titleMBL2 Gene Polymorphism and Risk of Vitiligo in Turkish Patientsen_US
dc.typeArticleen_US

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