Investigation of the efficacy on tyrosinase enzyme of 5-substituted-1H-tetrazole derivatives synthesized with Pd-containing nanoparticle

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dc.authoridAdem, Sevki/0000-0003-2146-5870en_US
dc.authorscopusid57485613000en_US
dc.authorscopusid58582053700en_US
dc.authorscopusid56610640700en_US
dc.authorscopusid23026885900en_US
dc.authorwosidAdem, Sevki/M-2108-2019en_US
dc.contributor.authorAydinli, Elif
dc.contributor.authorHameed, Zeyad Adil
dc.contributor.authorGoksu, Haydar
dc.contributor.authorAdem, Sevki
dc.date.accessioned2024-08-23T16:07:04Z
dc.date.available2024-08-23T16:07:04Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractSynthesis of 5-substituted-1H-tetrazole derivatives from aryl aldehydes under the influence of Palladium nanoparticles entrapped in aluminum hydroxide matrix (Pd/AlO(OH) NPs) was carried out in ethanol for 3-6 h. The use of the catalyst in this synthesis is the first. Sodium azide and malononitrile used in the reaction are chemical compounds required in the synthesis of tetrazoles. The reactions were concluded with good yields under thermal conditions. In the reactions, twelve derivatives were synthesized. The synthesized compounds were characterized by IR, 1H, and 13C NMR. The olefinic proton's signal, which is around 8.5 ppm, reveals the formation of the tetrazole ring. The tyrosinase enzyme activity for each synthesized derivative was examined, and the results were recorded. According to the results obtained, all tetrazole derivatives were found to be effective compounds for tyrosinase enzyme inhibition. 3-(3,4-dichlorophenyl)-2-(1H-tetrazol-5-yl)acrylonitrile (2k) with two chloride groups at the meta and para position of the phenyl ring seems to be the most potent tyrosinase inhibitor with an IC50 value of 45 mu M.Graphical abstractSYNOPSIS: 5-substituted-1H-tetrazole derivatives were synthesized under the influence of PdAlO(OH) NPs and under mild conditions. Tyrosinase enzyme activity was investigated for each of the twelve synthesized derivatives. As a result, synthesized tetrazole derivatives were identified as potential tyrosinase inhibitors.en_US
dc.description.sponsorshipDuzce University Research Fund [2022.26.07.1280]en_US
dc.description.sponsorshipThis research was supported by the Duzce University Research Fund (grant no. 2022.26.07.1280).en_US
dc.identifier.doi10.1007/s12039-024-02254-w
dc.identifier.issn0974-3626
dc.identifier.issn0973-7103
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85187805366en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1007/s12039-024-02254-w
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14467
dc.identifier.volume136en_US
dc.identifier.wosWOS:001183887400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIndian Acad Sciencesen_US
dc.relation.ispartofJournal of Chemical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTetrazoleen_US
dc.subjectTyrosinaseen_US
dc.subjectNanoparticleen_US
dc.subjectMushroom Tyrosinaseen_US
dc.subjectCrystal-Structureen_US
dc.subjectInhibitionen_US
dc.subjectTetrazolesen_US
dc.titleInvestigation of the efficacy on tyrosinase enzyme of 5-substituted-1H-tetrazole derivatives synthesized with Pd-containing nanoparticleen_US
dc.typeArticleen_US

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