General Principles, Designs, and Statistical Analyses in Experimental Animal Studies

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dc.authorscopusid8604063700en_US
dc.contributor.authorCangür, Ş.
dc.date.accessioned2024-08-23T16:07:30Z
dc.date.available2024-08-23T16:07:30Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractResearch using animals contributes significantly to many research and development studies, especially in the biomedical field. Within the scope of the study, conducting animal experiments in accordance with scientific principles and ensuring the ethical use and welfare of animals are issues that should be taken into consideration. In this context, the scientific contribution to be achieved by conducting these studies in line with scientific and ethical principles will be directly proportional. In many studies, while investigating the biological significance, it is seen that the effects of many factors are ignored, the answer to the biological question is investigated with simple experimental designs, or the accurate statistical analyses are not chosen. Therefore, in this study, the principles that a researcher planning an animal study should follow within the scope of the research (animal ethics, 3R, and other R rules, determination of sample size, randomization, and blinding) are briefly mentioned. Then, completely randomized design, regression design, split-unit design, hierarchical (nested) design, mixed effects design, and appropriate statistical analyses for these designs, which are thought to be useful in these studies, are discussed. It is thought that this review will be useful as it contains important summative information that will guide all researchers in planning animal studies accurately and quickly. © 2024, Duzce University Medical School. All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.1481602
dc.identifier.endpage18en_US
dc.identifier.issn1307-671X
dc.identifier.issueS1en_US
dc.identifier.scopus2-s2.0-85197483421en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage14en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.1481602
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14696
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorCangür, Ş.en_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject3R rules, 12R’sen_US
dc.subjectAnimal studyen_US
dc.subjectexperimental designsen_US
dc.subjectanimal experimenten_US
dc.subjectdrug developmenten_US
dc.subjectexperimental designen_US
dc.subjectnonhumanen_US
dc.subjectreviewen_US
dc.subjectsample sizeen_US
dc.subjectstatistical analysisen_US
dc.titleGeneral Principles, Designs, and Statistical Analyses in Experimental Animal Studiesen_US
dc.title.alternativeDeney Hayvanı Çalışmalarında Genel Prensipler, Tasarımlar ve İstatistiksel Analizleren_US
dc.typeReviewen_US

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