Rat brain and testicular tissue effects of radiofrequency radiation exposure: Histopathological, DNA damage of brain and qRT-PCR analysis

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dc.authoridVarol, Salih/0000-0002-9954-6657;
dc.contributor.authorYavas, M. C.
dc.contributor.authorKilitci, A.
dc.contributor.authorCelik, E.
dc.contributor.authorYegin, K.
dc.contributor.authorSirav, B.
dc.contributor.authorVarol, S.
dc.date.accessioned2025-10-11T20:47:36Z
dc.date.available2025-10-11T20:47:36Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: : The Background: We evaluate the effects of radiofrequency electromagnetic field (RF-EMF) on rat brain and testicular tissue using histopathology, comet assay, and real-time quantitative PCR techniques. Materials and Methods: Two equal groups of fourteen rats one for sham-control and the other for exposure (n = seven) were created. For a duration of 14 days, the exposure group (2100 MHz, testicular tissue SAR values of 163 mW/kg for 10 g, brain tissue SAR values of 292 mW/ kg on average) was subjected to five hours of exposure per day. Evaluations were conducted on tissue gene expression levels, histopathology, and DNA damage to brain tissue. Results: The histological examination of brain tissue from the exposed group revealed vascular alterations and significant edema (p < 0.05). It was determined that RF radiation-induced much more cellular damage in the exposed group (18.26% tail DNA) than in the control group (4.06% tail DNA). Signs of deterioration in spermatogenic cells in the testicular tissue of the exposed group also changed significantly (p < 0.05). The Bax and bcl-2 genes showed a significant difference (p < 0.05) in the mRNA level data, whereas the p53 genes showed no significant change (p > 0.05). Conclusion: These findings suggest that it may cause some histopathological and cellular damage in brain and testis tissue.en_US
dc.identifier.doi10.61186/ijrr.22.3.529
dc.identifier.endpage536en_US
dc.identifier.issn2322-3243
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85205991375en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage529en_US
dc.identifier.urihttps://doi.org/10.61186/ijrr.22.3.529
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21454
dc.identifier.volume22en_US
dc.identifier.wosWOS:001330764900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIjrr-Iranian Journal Radiation Resen_US
dc.relation.ispartofInternational Journal of Radiation Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subject2100 MHzen_US
dc.subjectBrainen_US
dc.subjectRadiationen_US
dc.subjectHistopathologicalen_US
dc.subjectqRT-PCRen_US
dc.subjectRadiofrequencyen_US
dc.subjectTesticularen_US
dc.titleRat brain and testicular tissue effects of radiofrequency radiation exposure: Histopathological, DNA damage of brain and qRT-PCR analysisen_US
dc.typeArticleen_US

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